Vnitr Lek 2012, 58(11):851-855

Multiple-combination kinezio-phlebothromboemboloprophylaxis, mechano-phlebothromboemboloprophylaxis and pharmaco-phlebothromboemboloprophylaxis of venous thromboembolism in internal medicine

P. Gavorník^*, Ľ. Gašpar, A. Dukát

II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, Prvé angiologické pracovisko (PAP), prednosta doc. MUDr. Ľudovít Gašpar, CSc.

Parenteral heparin and oral coumarin preparations represent the standard antithrombotics widely used in the prevention and treatment of venous thromboembolism (VTE). Unfractionated heparin, low molecular weight heparins, and fondaparinux have been shown to be effective and safe in reducing VTE risk. Despite high efficacy these medicaments have limitations which become to be more apparent with current widening of the indications for either primary thromboprophylaxis (PTP) or indefinite and even lifelong secondary thromboprophylaxis (STP). There is a need for new effective and safe medicaments with specific antithrombotic action, oral administration and convenient dosing without monitoring. During the last decade new antithrombotics have been developed either blocking selectively one coagulation enzyme or inhibiting particular step in coagulation cascade. Document of the Angiologists' Section of the Slovak Medical Chamber (AS SMC).

Keywords: veins; venous thromboembolism; (kinezio-mechano-pharmaco-) phlebothromboemboloprophylaxis; heparin; warfarin; new venous antithrombotics

Received: April 11, 2012; Accepted: May 29, 2012; Published: November 1, 2012  Show citation