Vnitr Lek 2013, 59(6):444-449

Impact of aortic stiffness on central hemodynamics and cardiovascular system

J. Bulas*, M. Potočárová, M. Filková, A. Šimková, J. Murín
I. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednostka doc. MUDr. Soňa Kiňová, PhD.

Arterial stiffness increases as a result of degenerative processes accelerated by aging and many risk factors, namely arterial hypertension. Basic clinical examination reveals increased pulse pressure as its hemodynamic manifestation. The most serious consequence of increased vascular stiffness, which cannot be revealed by clinical examination, is a change of central hemodynamics leading to increased load of left ventricle, left ventricular hypertrophy, diastolic dysfunction and to overall increase of cardiovascular risk. This review aimed to point at some patophysiological mechanisms taking part in the development of vascular stiffness, vascular remodeling and hemodynamic consequences of these changes. This work also gives an overview of non-invasive examination methods and their characteristics enabling to evaluate the local, regional and systemic arterial stiffness and central pulse wave analysis and their meaning for central hemodynamics and heart workload.

Keywords: aortic stiffness; cardiovascular risk; pulse wave velocity (PWV); augmentation index; wave reflexion; central blood pressure

Received: April 29, 2013; Published: June 1, 2013  Show citation

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Bulas J, Potočárová M, Filková M, Šimková A, Murín J. Impact of aortic stiffness on central hemodynamics and cardiovascular system. Vnitr Lek. 2013;59(6):444-449.
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