Vnitr Lek 2014, 60(2):110-113

Assessment of left ventricular diastolic function by radionuclide ventriculography in patients with chronic heart failure and reduced ejection fraction

Jan Naar¹, Filip Málek^1,*, Otto Lang², Otakar Bělohlávek³, Jana Vránová⁴, Tomáš Mráz¹, Eva Mandysová¹, Petr Neužil¹

¹ Department of Cardiology, Cardiocenter, Na Homolce Hospital, Prague, head prof. MUDr. Petr Neužil, CSc., FESC

² Department of Nuclear Medicine, Královské Vinohrady Faculty Hospital, Prague, head MUDr. Otto Lang, Ph.D.

³ Department of Nuclear Medicine, Na Homolce Hospital, Prague, head doc. MUDr. Otakar Bělohlávek, CSc.

⁴ Department of Medical Biophysics and Informatics, Third Faculty of Medicine, Charles University, Prague, dean prof. MUDr. Michal Anděl, CSc.

Study objective:
To compare parameters of diastolic function as assessed by radionuclide ventriculography (RNVG) and Doppler echocardiography (ECHO) in the patients with chronic heart failure and reduced ejection fraction (HF REF).

Patients and methods:
RNVG and ECHO were performed on the same day in 40 patients with systolic chronic HF, NYHA II and III, with LV EF < 50 % and sinus rhythm, followed at tertiary HF clinic. Diastolic function was assessed by RNVG using parameters: PFR (peak filling rate [% SV/sec]), TFR - time to peak filling rate (ms), and by ECHO using pulse Doppler parameters: the peak Doppler velocities of early (E) and late diastolic flow (A), the E/A ratio, the calculated mean of the early (E') diastolic velocity of septal and lateral mitral annulus measured by tissue Doppler imaging, and the E/E' ratio.

Results:
The mean PFR was 421.7 (median 371.0) % SV/sec and TPF was 198.7 ms (median 169.5), the mean E/A ratio was 1.21 (median 0.85) and the E/E' ratio was 9.0 (median 8.40). TPF correlated significantly (inverse correlation) with the E/A ratio (r = -0.34, p = 0.030), and not significantly with E' (r = -0.27, p = 0.082), the PFR/age ratio correlated with the E/E' ratio (r = -0.31, p = 0.05).

Conclusion:
Significant correlations of parameters of diastolic function as assessed by radionuclide and Doppler studies were identified in the HF REF patients.

Keywords: diastolic function; Doppler echocardiography; heart failure with reduced ejection fraction; radionuclide ventriculography

Received: August 6, 2013; Accepted: September 16, 2013; Published: February 1, 2014  Show citation