Vnitr Lek 2014, 60(7-8):595-600

Specifics of diabetes mellitus in women

Ludmila Brunerová1,*, Jan Brož2
1 Diabetologické centrum II. interní kliniky 3. LF UK a FN Královské Vinohrady Praha, přednosta prof. MUDr. Michal Anděl, CSc.
2 Diabetologické centrum Interní kliniky 2. LF UK a FN Motol Praha, přednosta prof. MUDr. Milan Kvapil, CSc., MBA

Approximately 4 % of female population suffers from diabetes. A permanent interaction between diabetes, its treatment and sex hormonal changes (childhood, puberty, reproduction, pregnancy, menopause) occurs in those women. This review article summarizes up to date published studies concerning reciprocal relationship between diabetes and sexual development in women.

Keywords: diabetes mellitus; gestation; hormonal contraceptive; hyperandrogenism; menopause; puberty; sex hormones

Received: March 19, 2014; Accepted: May 18, 2014; Published: July 1, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Brunerová L, Brož J. Specifics of diabetes mellitus in women. Vnitr Lek. 2014;60(7-8):595-600.
Download citation

References

  1. Livingstone C, Collison M. Sex steroids and insulin resistance. Clin Sci (Lond) 2002; 102(2): 151-166. Go to original source... Go to PubMed...
  2. Hollingsworth DR. Alterations of maternal metabolism in normal and diabetic pregnancies: difference in insulin dependent, non-insulin dependent and gestational diabetes. Am J Obstet Gynecol 1983; 146(4): 417-429. Go to original source... Go to PubMed...
  3. Godsland IF, Walton C, Felton C et al. Insulin resistance, secretion and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 1992; 74(1): 64-70. Go to original source...
  4. Wada T, Hori S, Sugiyama M et al. Progesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2010; 298(4): E881-E888. Go to original source... Go to PubMed...
  5. Woodward TS, Burghen GZ, Kitabachi AE et al. Glucose intolerance and insulin resistance in aplastic anaemia treated with oxymetholone. J Clin Endocrinol Metab 1981; 53(5): 905-908. Go to original source... Go to PubMed...
  6. Hollingsworth DR. Alterations of maternal metabolism in normal and diabetic pregnancies: difference in insulin dependent, non-insulin dependent and gestational diabetes. Am J Obstet Gynecol 1983; 146(4): 417-429. Go to original source... Go to PubMed...
  7. Polderman KH, Gooren LJG, Asscheman H et al. Induction of insulin resistance by androgens and estrogens. J. Clin Endocrinol Metab 1994; 79(1): 265-271. Go to original source...
  8. Kumagai S, Holmang A, Bjornthorp P. The effects of oestrogen and progesterone on insulin sensitivity in female rats. Acta Physiol Scand 1993; 149(1): 91-97. Go to original source... Go to PubMed...
  9. Tsibris JCM, Raynor LO, Buhi WC et al. Insulin receptors in circulating erythrocytes and monocytes from women on oral contraceptives or pregnant women near term. J Clin Endocrinol Metab 1980; 51(4): 711-717. Go to original source... Go to PubMed...
  10. Moran C, Huerta L, Conway-Myers BA et al. Altered autophosphorylation of the insulin receptor in the ovary of a woman with polycystic ovarian syndrome. Fertil Steril 2001; 75(3): 635-638. Go to original source... Go to PubMed...
  11. Rosenbaum D, Haber RS, Dunaif A. Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT4 glucose transporters in adipocytes. Am J Physiol 1993; 264(2 Pt 1): E197-E202. Go to original source... Go to PubMed...
  12. Silverstein JH, Rosenbloom AL. The journey to metabolic control in diabetes: many more miles to go. J Pediatr 2003; 143(6): 704-706. Go to original source... Go to PubMed...
  13. Jovanovic L. Advances in diabetes for the millennium: diabetes in women. Med Gen Med 2004; 6(Suppl 3): 3.
  14. Silbernagl S, Despopulos A. Atlas fyziologie člověka. Grada: Praha 1993: 262-263. ISBN 80-85623-79-X.
  15. Escalante Pulido JM, Alpizar Salazar M. Changes in insulin sensitivity, secretion and glucose effectiveness during menstrual cycle. Arch Med Res 1999; 30(1): 19-22. Go to original source... Go to PubMed...
  16. Trout KK, Rickels MR, Schutta MH et al. Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study. Diabetes Technol Ther 2007; 9(2): 176-182. Go to original source... Go to PubMed...
  17. Goldner WS, Kraus VL, Sivitz WI et al. Cyclic changes in glycemia assessed by continuous glucose monitoring system during multiple complete menstrual cycles in women with type 1 diabetes. Diabetes Technol Ther 2004; 6(4): 473-480. Go to original source... Go to PubMed...
  18. Cibula D, Henzl MR, Živný J et al. Základy gynekologické endokrinologie. Grada: Praha 2002: 21-26. ISBN 80-247-0236-3.
  19. Farrell T, Neale L, Cundy T. Congenital anomalies in the offspring of women with type 1, type 2 and gestational diabetes. Diabet Med 2002; 19(4): 322-326. Go to original source... Go to PubMed...
  20. Moley KH. Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women. Trends Endocrinol Metab 2001; 12(2): 78-82. Go to original source... Go to PubMed...
  21. Greene MF. Spontaneous abortions and major malformations in women with diabetes mellitus. Semin Reprod Endocrinol 1999; 17(2): 127-136. Go to original source... Go to PubMed...
  22. Chang AS, Dale AN, Moley KH. Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis. Endocrinology 2005; 146(5): 2445-2453. Go to original source... Go to PubMed...
  23. Al-Agha R, Firth RG, Byrne M et al. Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes-obstetrical clinics in Dublin in three university teaching hospitals (1995-2006). Ir J Med Sci 2012; 181(1): 105-109. Go to original source... Go to PubMed...
  24. Dunne F, Brydon P, Smith K et al. Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med 2003; 20(9): 734-738. Go to original source... Go to PubMed...
  25. Maso G, Piccoli M, Parolin S et al. Diabetes in pregnancy: timing and mode of delivery. Curr Diab Rep 2014; 14(7): 506. Go to original source... Go to PubMed...
  26. Franconi F, Campesi I, Occhioni S et al. Sex-gender differences in diabetes vascular complications and treatment. Endocr Metab Immune Disord Drug Targets 2012; 12(2):179-196. Go to original source... Go to PubMed...
  27. Salonia A, Lanzi R, Scavini M et al. Sexual function and endocrine profile in fertile women with type 1 diabetes. Diabetes Care 2006; 29(2): 312-316. Go to original source... Go to PubMed...
  28. Strotmeyer ES, Steenkiste AR, Foley jr. TP Menstrual cycle differences between women with type 1 diabetes and women without diabetes. Diabetes Care 2003; 26(4): 1016-1021. Go to original source... Go to PubMed...
  29. Šnajderová M, Martínek J, Hořejší J et al. Premenarchal and postmenarchal girls with insulin-dependent diabetes mellitus: ovarian and other organ-specific autoantibodies, menstrual cycle. J Pediatr Adolesc Gynecol 1999; 12(4): 209-214. Go to original source... Go to PubMed...
  30. Schroeder B, Hertweck SP, Sanfilippo JS et al. Correlation between glycemic control and menstruation in diabetic adolescents. J Reprod Med 2000; 45(1): 1-5. Go to PubMed...
  31. Deltsidou A, Lemonidou C, Zarikas V et al. Oligomenorrhoea in adolescents with type 1 diabetes mellitus: relationship to glycaemic control. Eur J Obstet Gynecol Reprod Biol 2010; 153(1): 62-66. Go to original source... Go to PubMed...
  32. Codner E, Eyzaguirre FC, Iñiguez G et al. Chilean Group for the Study of Ovarian Function in Type 1 Diabetes. Ovulation rate in adolescents with type 1 diabetes mellitus. Fertil Steril 2011; 95(1): 197-202. Go to original source... Go to PubMed...
  33. Yencilek F, Attar R, Erol B et al. Factors affecting sexual function in premenopausal age women with type 2 diabetes: a comprehensive study. Fertil Steril 2010; 94(5): 1840-1843. Go to original source... Go to PubMed...
  34. Otunctemur A, Dursun M, Ozbek E et al. Impact of Metabolic Syndrome on Sexual Function in Pre- and Post-Menopausal Women. J Sex Marital Ther 2014; May 13: 1-10. [Epub ahead of print].
  35. Solomon CG, Hu FB, Dunaif A et al. Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA 2001; 286(19): 2421-2426. Go to original source... Go to PubMed...
  36. Shim U, Oh JY, Lee HJ et al. Long menstrual cycle is associated with type 2 diabetes mellitus in korean women. Diabetes Metab J 2011; 35(4): 384-389. Go to original source... Go to PubMed...
  37. Dishi M, Enquobahrie DA, Abetew DF et al. Age at menarche, menstrual cycle characteristics and risk of gestational diabetes. Diabetes Res Clin Pract 2011; 93(3): 437-442. Go to original source... Go to PubMed...
  38. Ehrmann DA, Barnes RB, Rosenfield RL et al. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 1999; 22(1): 141-146. Go to original source... Go to PubMed...
  39. Plymate SR, Matej LA, Jones RE et al. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 1988; 67(3): 460-464. Go to original source... Go to PubMed...
  40. Salley KE, Wickham EP, Cheang KI et al. Glucose intolerance in polycystic ovary syndrome: a position statement of the Androgen Excess Society. J Clin Endocrinol Metab 2007; 92(12): 4546-4556. Go to original source... Go to PubMed...
  41. Lashen H. Role of metformin in the management of polycystic ovary syndrome. Ther Adv Endocrinol Metab 2010; 1(3): 117-128. Go to original source... Go to PubMed...
  42. Bizzarri C, Benevento D, Ravà L et al. Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index. Fertil Steril 2011; 96(6): 1497-1502. Go to original source... Go to PubMed...
  43. Denoble AE, Hall KS, Xu X et al. Receipt of Prescription Contraception by Commercially Insured Women With Chronic Medical Conditions. Obstet Gynecol 2014; 123(6): 1213-1220. Go to original source... Go to PubMed...
  44. Shawe J, Mulnier H, Nicholls P et al. Use of hormonal contraceptive methods by women with diabetes. Prim Care Diabetes. 2008; 2(4): 195-199. Go to original source... Go to PubMed...
  45. Napoli A, Colatrella A, Botta R et al. Italian diabetic pregnancy study group (sid). contraception in diabetic women: an italian study. Diabetes Res Clin Pract 2005; 67(3): 267-272. Go to original source... Go to PubMed...
  46. Lawrenson RA, Leydon GM, Williams TJ et al. Patterns of contraception in UK women with Type 1 diabetes mellitus: a GP database study. Diabet Med 1999; 16(5): 395-399. Go to original source... Go to PubMed...
  47. Visser J, Snel M, Van Vliet HA. Hormonal versus non-hormonal contraceptives in women with diabetes mellitus type 1 and 2. Cochrane Database Syst Rev 2006; 4: CD003990. Go to original source... Go to PubMed...
  48. Sadloňová J. Možnosti hormonální antikoncepce a substituce u diabetiček. Vnitř Lék 2009; 55(4): 375-383. Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.