Vnitr Lek 2015, 61(2):129-133

The new drug is much more effective than ACE inhibitors in chronic heart failure

Jiří Widimský sr
Klinika kardiologie IKEM Praha, přednosta prof. MUDr. Josef Kautzner, CSc.

PARADIGM-HF study observed clinical outcomes after treatment by new drug LCZ696 or enalapril in patients with systolic chronic heart failure. It was randomized double-blind trial with LCZ696 (200 mg twice a day) and enalapril (10 mg twice a day). 8442 patients were enrolled with NYHA class II or III and left ventricular ejection fiction of 40% or less. Study drugs were added to other recommended medication. The trial was prematurely terminated after median follow-up of 27 months. The primary endpoint of the study was a combination of cardiovascular mortality and the first hospitalization for heart failure. LCZ696 drug, an inhibitor of angiotensin receptor and neprilysin (Arnie), has led to a reduction in the primary composite target by 20% (p

Keywords: ARNi study; LCZ696; PARADIGM-HF

Received: December 15, 2014; Accepted: December 16, 2014; Published: February 1, 2015  Show citation

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Widimský J. The new drug is much more effective than ACE inhibitors in chronic heart failure. Vnitr Lek. 2015;61(2):129-133.
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