Vnitr Lek 2015, 61(2):147-150

Insulin analogues of patients with diabetes and renal impairment

Alena Adamíková

Diabetologické centrum Interní kliniky Krajské nemocnice T. Bati, a.s., Zlín, přednosta prim. MUDr. Jiří Latta

The main cause of renal failure is diabetic nephropathy which affects 20-40 % of diabetic patients. Diabetics with altered renal function have restricted therapeutic options due to the risk of accumulation of oral antidiabetic drugs and of their metabolites at a reduced glomerular filtration rate. Good metabolic control is very important during the early phases of nephropathy for reducing the risk of progression and in the stage of renal failure reduces the risk of progression of atherosclerosis and improves life prognosis. Metabolism of insulin is changed during renal failure, clearance of insulin is prolonged, the risk of hypoglycemia increases. Short-acting insulin analogues have faster absorption and long-acting analogues have a lower risk of hypoglycemia. Thus they can positively affect glycemic control of patients with diabetes and impaired renal function.

Keywords: diabetic nephropathy; insulin analogues; renal impairment

Received: January 30, 2015; Accepted: February 27, 2015; Published: February 1, 2015  Show citation