Vnitr Lek 2016, 62(11):882-886
Hyperlipoproteinemia in children
- Klinika dětského a dorostového lékařství 1. LF UK a VFN v Praze
Hyperlipoproteinemia (HLP) is one of the most common metabolic disorder in childhood. We assume that 20 % of children have a disorder of the lipid metabolism. Some HLP are very common in the population, and moderate, and some are very rare, but are very severe. These may occur secondary to pathological conditions, or are formed on the basis of the primary monogenic or polygenic disorders of lipid metabolism. The detection of children with HLP in the Czech Republic is either random, or more often by selective screening of children with familial history of cardiovascular disease, provided by general pediatric practitioners for children and adolescents. Treatment in childhood is primarily dietetic, some of them, especially children with familial hypercholesterolemia are treated from 8-10 years pharmacologically.
Keywords: diagnosis; hyperlipoproteinemia; children; treatment
Received: September 22, 2016; Accepted: October 17, 2016; Published: November 1, 2016 Show citation
References
- Berenson GS, Srinivasan S, Bao W et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults: the Bogalusa Heart Study. N Engl J Med 1998; 338(23): 1650-1656.
Go to original source... 
Go to PubMed... - Šamánek M, Urbanová Z. Prevence aterosklerózy v dětském věku. Galén: Praha 2003. ISBN 80-7262-229-3.
- Češka R. Diagnostika a léčba hyperlipoproteinémií. Triton: Praha 2003. ISBN 80-7254-328-8.
- National Cholesterol Education Program (NCEP): highlights of the report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics 1992; 89(3):495-501. Go to original source... Go to PubMed...
- Urbanová Z, Šamánek M, Češka R et al. Doporučení pro diagnostiku a léčbu dyslipidemií u dětí a dospívajících, vypracované výborem České společnosti pro aterosklerózu. Cor et Vasa 2008; 50(2): K41-K47.
- Kavey RW, Stephen R, Lauer MR et al. American Heart Association Guidelines for Primary Prevention of Atherosclerotic Cardiovascular Disease Beginning in Childhood. Circulation 2003; 107(11): 1562-1566. Go to original source... Go to PubMed...
- Stephen R, Daniels MD, Gidding SS et al. Pediatric aspects of Familial Hypercholesterolemia: Recommendation from the National Lipid Association Expert Panel on Familial hypercholesterolemia. J Clin Lipidol 2011; 5(3 Suppl): S30-S37. Dostupné z DOI: <http://dx.doi.org/http://dx.doi.org/10.1016/j.jacl.2011.03.453>. Go to original source... Go to PubMed...
- Wiegman A, Gidding S, Wats GF et al. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J 2015; 36(36): 2425-37. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehv157>. Go to original source... Go to PubMed...
- Bibbins-Domingo K, Grossman DC, Curry SJ et al. [US Preventive Services Task Force]. Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. JAMA 2016; 316(6): 625-633. Dostupné z DOI: <http://dx.doi.org/10.1001/jama.2016.9852>. Go to original source... Go to PubMed...
- Urbanová Z, Freiberger T, Šamánek M et al. Komentář k souhrnu konsenzu panelu experů European Atherosclerotic Society k otázce optimalizace diagnostiky a léčby dětí s familiární hypercholesterolemií. Hypertenze a kardiovaskulární prevence 2016; 5(1): 36-38. Dostupné z WWW: <http://www.hypertension.cz/sqlcache/csh-01-2016-web.pdf>.