Vnitr Lek 2016, 62(Suppl 3):107-114

Psycho-immuno-endocrinology of the thyroid gland

Ivan Šterzl*, Karolína Absolonová, Petr Matucha
Oddělení klinické imunoendokrinologie Endokrinologického ústavu, Praha

Historically endocrinologists and psychiatrists are aware that disturbances in thyroid disease in beginning or even in clinically intensified states of thyrotoxicosis or hypothyroidism exhibit pathological mental manifestations, masking or potentiating the underlying disease. Immune system disorders cause thyroid organ-specific autoimmune process. This autoimmune thyroid disease binds with a number of disorders in both endocrine or non-endocrine organs. This appears in vascular, neurological, skin, connective tissue, gastrointestinal tract and mental pathology. These disorders are part of autoimmune polyglandular syndromes (APS) type I -III, especially the APS type III. Originally it was assumed that these mental disorders are caused by direct exposure to excess or deficiency of thyroid hormones. Recently, however, it appears that these psycho-immune-endocrine disorders have common etiologic mechanisms of formation and on cellular and molecular level they involve similar, if not in some cases, common mechanisms.

Keywords: antithyroid peroxidase antibody; autoimmune polyglandular syndrome type I., II., III.; autoimmune thyroid disease; bipolar disorder; depression; Hashimoto's encephalopathy; postpartum psychosis; psycho-immuno-endocrinology; schizophrenia

Received: June 28, 2016; Accepted: September 1, 2016; Published: June 1, 2016  Show citation

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Šterzl I, Absolonová K, Matucha P. Psycho-immuno-endocrinology of the thyroid gland. Vnitr Lek. 2016;62(Supplementum 3):107-114.
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