Vnitr Lek 2018, 64(3):272-279 | DOI: 10.36290/vnl.2018.038
Splanchnic vein thrombosis
- 1 Interní gastroenterologická klinika LF MU a FN Brno, pracoviště Bohunice
- 2 Oddělení klinické hematologie FN Brno, pracoviště Bohunice
- 3 Klinika radiologie a nukleární medicíny LF MU a FN Brno, pracoviště Bohunice
Splanchnic vein thrombosis (SVT) represents an unusual manifestation of venous thromboembolism. The etiological factors for SVT can be divided into local and systemic, frequently found concurrently. SVT can be the first presenting symptom in myeloproliferative neoplasms. SVT puts the patients affected in jeopardy of developing the intestinal infarction, impairing the liver function and portal hypertension development with the risk of potentially life-threatening gastrointestinal bleeding. The current guidelines emphasise the role of anticoagulation in acute splanchnic thrombosis. Considering the potentially fatal complications it is necessary to tailor the anticoagulant treatment individually. The duration of anticoagulant therapy is strongly dependent upon the risk evaluation of thrombosis recurrence. The article deals with the causes, diagnostic methods and aspects influencing the therapeutic strategy.
Keywords: anticoagulation; liver cirrhosis; portal hypertension; prothrombotic state; splanchnic vein thrombosis
Received: April 19, 2017; Accepted: October 19, 2017; Published: March 1, 2018 Show citation
References
- Hirmerová J, Karetová D, Malý R et al. Akutní žilní trombóza 2014: Současný stav prevence, diagnostiky a léčby. Doporučený postup české angiologické společnosti ČSL JEP 2014; 1-68. Dostupné z WWW: <https://www.csth.cz/soubory/Zilni_tromboza_doporuceni.pdf>.
- Rokyta R, Hutyra M, Jansa P. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. Summary document prepared by the Czech Society of Cardiology. Cor Vasa 2015; 57(4): e275-e296.
Go to original source...
- Kearon C, Akl EA, Ornelas J et al. Antithrombotic Therapy for VTE Disease. Chest 2016; 149(2): 315-352. Dostupné z DOI: <http://dx.doi.org/10.1016/j.chest.2015.11.026>.
Go to original source...
Go to PubMed...
- Ageno W, Riva N, Schulman S et al. Long-term Clinical Outcomes of Splanchnic Vein Thrombosis. JAMA Intern Med 2015; 175(9): 1474. Dostupné z DOI: <http://dx.doi.org/10.1001/jamainternmed.2015.3184>.
Go to original source...
Go to PubMed...
- Hmoud B, Singal A, Kamath P. Mesenteric Venous Thrombosis. J Clin Exp Hepatol 2014; 4(3): 257-263. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jceh.2014.03.052>.
Go to original source...
Go to PubMed...
- [European Association for the Study of the Liver]. EASL Clinical Practice Guidelines: Vascular diseases of the liver. J Hepatol 2016; 64(1): 179-202. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2015.07.040>.
Go to original source...
Go to PubMed...
- Šembera Š, Hůlek P, Jirkovský V et al. Prehepatic portal hypertension. Gastroent Hepatol 2016; 70(5): 432-437. Dostupné z DOI: <http://dx.doi.org/10.14735/amgh2016432>.
Go to original source...
- Ehrmann J, Hůlek P. Hepatologie. Grada: Praha 2010. ISBN 978-80-247-3118-6.
- Ageno W, Dentali F, Squizzato A. How I treat splanchnic vein thrombosis. Blood 2014; 124(25): 3685-3691. Dostupné z DOI: <http://dx.doi.org/10.1182/blood-2014-07-551515>.
Go to original source...
Go to PubMed...
- Riva N, Donadini M, Dentali F et al. Clinical approach to splanchnic vein thrombosis: Risk factors and treatment. Thromb Res 2012; 130(Suppl 1): S1-S3. Dostupné z DOI: <http://dx.doi.org/10.1016/j.thromres.2012.08.259>.
Go to original source...
Go to PubMed...
- Arber DA, Orazi A, Hasserjian R et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127(20): 2391-2405. Dostupné z DOI: <http://dx.doi.org/10.1182/blood-2016-03-643544>.
Go to original source...
Go to PubMed...
- Primignani M. Portal vein thrombosis, revisited. Dig Liver Dis 2010; 42(3): 163-170. Dostupné z DOI: <http://dx.doi.org/10.1016/j.dld.2009.08.003>.
Go to original source...
Go to PubMed...
- Boggs W. Anticoagulant Improves Outcome of Incidentally Detected Splanchnic Vein Thrombosis. Medscape 2016. Dostupné z WWW: <http://chronicliverdisease.org/reuters/article.cfm?article=20160602Scie1762166889⊤ic=scie>.
- Condat B, Vilgrain V, Asselah T et al. Portal cavernoma-associated cholangiopathy: A clinical and MR cholangiography coupled with MR portography imaging study. Hepatology 2003; 37(6): 1302-1308. <http://dx.doi.org/10.1053/jhep.2003.50232>.
Go to original source...
Go to PubMed...
- Weber P, Procházka L, Kala Z et al. Mezenterická ichemie a mezenterická žilní trombóza v geriatrické medicíně. Čes Ger Rev 2008; 6(3): 161-164. Dostupné z WWW: <http://www.prolekare.cz/pdf?ida=gr_08_03_08.pdf>.
- Darwish Murad S, Plessier A, Hernandez-Guerra M et al. Etiology, Management, and Outcome of the Budd-Chiari Syndrome. Ann Intern Med 2009; 151(3): 167-175.
Go to original source...
Go to PubMed...
- Plessier A, Rautou PE, Valla DC. Management of hepatic vascular diseases. J Hepatol 2012; 56(Suppl 1): S25-S38. Dostupné z DOI: <http://dx.doi.org/10.1016/S0168-8278(12)60004-X>.
Go to original source...
Go to PubMed...
- Valla DC. Splanchnic Vein Thrombosis. Semin Thromb Hemost 2015; 41(5): 494-502. Dostupné z DOI: <http://dx.doi.org/10.1055/s-0035-1550439>.
Go to original source...
Go to PubMed...
- Okumura A, Watanabe Y, Dohke M et al. Contrast-enhanced Three-dimensional MR Portography. Radiographics 1999; 19(4): 973-987. <http://dx.doi.org/10.1148/radiographics.19.4.g99jl02973>.
Go to original source...
Go to PubMed...
- Seijo S, Reverter E, Miquel R et al. Role of hepatic vein catheterisation and transient elastography in the diagnosis of idiopathic portal hypertension. Dig Liver Dis 2012; 44(10): 855-860. Dostupné z DOI: <http://dx.doi.org/10.1016/j.dld.2012.05.005>.
Go to original source...
Go to PubMed...
- De Francis R. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol 2015; 63(3): 743-752. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2015.05.022>.
Go to original source...
Go to PubMed...
- Zhang D, Hao J, Yang N. Protein C and D-dimer are related to portal vein thrombosis in patients with liver cirrhosis. J Gastroenterol Hepatol 2010; 25(1): 116-121. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1440-1746.2009.05921.x>.
Go to original source...
Go to PubMed...
- Dai J, Qi X, Peng Y et al. Association between D-dimer level and portal venous system thrombosis in liver cirrhosis: a retrospective observational study. Int J Clin Exp Med 2015; 8(9): 15296-15301.
- Čingerová L, Kučeráková M. Trombofília. Vnitř Lék 2016; 62(12): 985-989.
Go to PubMed...
- Sarin S, Sollano J, Chawla Y et al. Consensus on extra-hepatic portal vein obstruction. Liver Int 2006; 26(5): 512-519. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1478-3231.2006.01269.x>.
Go to original source...
Go to PubMed...
- Plessier A, Darwish-Murad S, Hernandez-Guerra M et al. Acute portal vein thrombosis unrelated to cirrhosis: A prospective multicenter follow-up study. Hepatology 2010; 51(1): 210-218. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.23259>.
Go to original source...
Go to PubMed...
- Amitrano L, Guardascione M, Scaglione M et al. Prognostic Factors in Noncirrhotic Patients With Splanchnic Vein Thromboses. Am J Gastroenterol 2007; 102(11): 2464-2470. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1572-0241.2007.01477.x>.
Go to original source...
Go to PubMed...
- Turnes J, García-Pagán J, González M et al. Portal Hypertension-Related Complications After Acute Portal Vein Thrombosis: Impact of Early Anticoagulation. Clin Gastroenterol Hepatol 2008; 6(12): 1412-1417. Dostupné z DOI: <http://dx.doi.org/10.1016/j.cgh.2008.07.031>.
Go to original source...
Go to PubMed...
- Condat B, Pessione F, Denninger MH et al. Recent Portal or Mesenteric Venous Thrombosis: Increased Recognition and Frequent Recanalization on Anticoagulant Therapy. Hepatology 2000; 32(3): 466-470. Dostupné z DOI: <http://dx.doi.org/10.1053/jhep.2000.16597>.
Go to original source...
Go to PubMed...
- Luca A, Caruso S, Milazzo M et al. Natural Course of Extrahepatic Nonmalignant Partial Portal Vein Thrombosis in Patients with Cirrhosis. Radiology 2012; 265(1): 124-132. Dostupné z DOI: <http://dx.doi.org/10.1148/radiol.12112236>.
Go to original source...
Go to PubMed...
- Nery F, Chevret S, Condat B et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study. Hepatology 2015; 61(2): 660-667. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.27546>.
Go to original source...
Go to PubMed...
- Singal A, Kamath P, Tefferi A. Mesenteric Venous Thrombosis. Mayo Clin Proc 2013; 88(3): 285-294. Dostupné z DOI: <http://dx.doi.org/10.1016/j.mayocp.2013.01.012>.
Go to original source...
Go to PubMed...
- Kumar S, Sarr M, Kamath P. Mesenteric Venous Thrombosis. N Engl J Med 2001; 345(23): 1683-1688. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMra010076>.
Go to original source...
Go to PubMed...
- Ďulíček P, Malý J. Budd-Chiari syndrom - úloha hematologa v multidisciplinárním přístupu. Vnitř Lék 2008; 54(9): 842-845.
Go to PubMed...
- Spahr L, Boehlen F, De Moerloose et al. Anticoagulants in portal vein thrombosis: don't be so shy!. Blood 2009; 113(20): 5031-5032. Dostupné z DOI: <http://dx.doi.org/10.1182/blood-2009-02-202770>.
Go to original source...
Go to PubMed...
- Condat B, Pessione F, Hillaire S et al. Current outcome of portal vein thrombosis in adults: Risk and benefit of anticoagulant therapy. Gastroenterology 2001; 120(2): 490-497.
Go to original source...
Go to PubMed...
- Janoušek L, Adamec M, Oliverius M et al. Transplantace jater u pacientů s trombózou v. portae. Čas Lék Čes 2011; 150(1): 72-74.
- Tait C, Baglin T, Watson H et al. Guidelines on the investigation and management of venous thrombosis at unusual sites. Br J Haematol 2012; 159(1): 28-38. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365-2141.2012.09249.x>.
Go to original source...
Go to PubMed...
- Karetová D, Bultas J Rozšiřující se možnosti antikoagulační léčby tromboembolické nemoci. Vnitř Lék 2014; 60(11): 977-984.
Go to PubMed...
- De Gottardi A, Trebicka J, Klinger C et al. Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis. Liver Int. 2017; 37(5):694-699. Dostupné z DOI: <http://dx.doi.org/10.1111/liv.13285>.
Go to original source...
Go to PubMed...
- Khoury T, Ayman A, Cohen J et al. The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going. Digestion 2016; 93(2): 149-159. Dostupné z DOI: <http://dx.doi.org/10.1159/000442877>.
Go to original source...
Go to PubMed...
- Intagliata NM, Henry ZH, Maitland H et al. Direct Oral Anticoagulants in Cirrhosis Patients Pose Similar Risks of Bleeding When Compared to Traditional Anticoagulation. Dig Dis Sci 2016; 61(6): 1721-1727. Dostupné z DOI: <http://dx.doi.org/10.1007/s10620-015-4012-2>.
Go to original source...
Go to PubMed...
- Hum J, Shatzel JJ, Jou JH et al. The efficacy and safety of direct oral anticoagulants vs traditional anticoagulants in cirrhosis. Eur J Haematol 2017; 98(4): 393-397. Dostupné z DOI: <http://dx.doi.org/10.1111/ejh.12844>.
Go to original source...
Go to PubMed...
- Delgado M, Seijo S, Yepes I et al. Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis. Clin Gastroenterol Hepatol 2012; 10(7): 776-783. Dostupné z DOI: <http://dx.doi.org/10.1016/j.cgh.2012.01.012>.
Go to original source...
Go to PubMed...
- Villa E, Cammà C, Marietta M et al. Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis. Gastroenterology 2012; 143(5): 1253-1260. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2012.07.018>.
Go to original source...
Go to PubMed...
- Vivarelli M, Zanello M, Zanfi C et al. Prophylaxis for venous thromboembolism after resection of hepatocellular carcinoma on cirrhosis: Is it necessary? World J Gastroenterol 2010; 16(17): 2146-2150.
Go to original source...
Go to PubMed...
- Senzolo M, Sartori TM, Rossetto V et al. Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis. Liver Int 2012; 32(16): 919-927. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1478-3231.2012.02785.x>.
Go to original source...
Go to PubMed...
- Acosta S, Alhadad A, Svensson P et al. Epidemiology, risk and prognostic factors in mesenteric venous thrombosis. Br J Surg 2008; 95(10): 1245-1251. Dostupné z DOI: <http://dx.doi.org/10.1002/bjs.6319>.
Go to original source...
Go to PubMed...
- Clavien PA, Dürig M, Harder F. Venous mesenteric infarction: A particular entity. Br J Surg 1988; 75(3): 252-255.
Go to original source...
Go to PubMed...
- Riva N, Ageno W, Poli D et al. Safety of vitamin K antagonist treatment for splanchnic vein thrombosis: a multicenter cohort study. J Thromb Haemost 2015; 13(6): 1019-1027. Dostupné z DOI: <http://dx.doi.org/10.1111/jth.12930>.
Go to original source...
Go to PubMed...
- Spaander M, Hoekstra J, Hansen B et al. Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding. J Thromb Haemost 2013; 11(3): 452-459. Dostupné z DOI: <http://dx.doi.org/10.1111/jth.12121>.
Go to original source...
Go to PubMed...