Vnitr Lek 2018, 64(10):934-938 | DOI: 10.36290/vnl.2018.130

Obstructive sleep apnea and dyslipidemia

Pavel Šiarnik1,*, Katarína Klobučníková1, Imrich Mucska2, Katarína Černá3, Branislav Kollár1, Peter Turčáni1
1 I. neurologická klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava, Slovenská republika
2 Ambulancia pre spánkové poruchy dýchania, UNB, Nemocnica Staré Mesto, Bratislava, Slovenská republika
3 Diabetologická ambulancia, UNB, Nemocnica akademika Ladislava Dérera, Bratislava, Slovenská republika

Obstructive sleep apnea is a sleep disorder characterized by repetitive partial or complete upper airway obstruction that lead to hemodynamic changes, arousals from sleep and intermittent hypoxia. Obstructive sleep apnea activates multiple pathways that lead to vascular disease. The vascular risk imposed by obstructive sleep apnea may be mediated through the metabolic consequences of sleep-disordered breathing. There is increasing evidence that obstructive sleep apnea is independently associated with dyslipidemia, a well known vascular risk factor. However, the role of obstructive sleep apnea in causality of dyslipidemia remains to be established. Current article focuses on possible mechanisms linking obstructive sleep apnea with the development of dyslipidemia. Possible role of obstructive sleep apnea as a therapeutic target to improve dyslipidemia is also discussed.

Keywords: dyslipidemia; obstructive sleep apnea

Received: December 7, 2017; Accepted: April 23, 2018; Published: October 1, 2018  Show citation

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Šiarnik P, Klobučníková K, Mucska I, Černá K, Kollár B, Turčáni P. Obstructive sleep apnea and dyslipidemia. Vnitr Lek. 2018;64(10):934-938. doi: 10.36290/vnl.2018.130.
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