Vnitr Lek 2020, 66(4):e22-e27 | DOI: 10.36290/vnl.2020.076

Lung diseases and autoimmune hemolytic anemia associted with IgG4 disease

Martina Doubková¹, Radoslav Matěj², Zita Chovancová³, Michael Doubek^4,5

¹ Klinika nemocí plicních a tuberkulózy LF MU a FN Brno, pracoviště Bohunice

² Ústav patologie a molekulární medicíny 3. LF UK a Thomayerovy nemocnice, Praha

³ Ústav klinické imunologie a alergologie LF MU a FN u sv. Anny Brno

⁴ Interní hematologická a onkologická klinika LF MU a FN Brno pracoviště Bohunice

⁵ Středoevropský technologický institut MU Brno

IgG4 related disease (IgG4-RD) is a rare and relatively new group of systemic inflammatory diseases characterized by inflammatory, fibrotic or sclerotic involvement of one or more organs accompanied by increased IgG4 plasma cells tissue infiltration and usually elevated serum IgG4 (IgG4 > 1.35g/l, normal range 0.08-1.40 g/l) level. Histopathological findings are crucial for the diagnostics of this disease. The authors present a case report of a patient with IgG4 associated disease manifested by a rare combination of autoimmune hemolytic anemia and pulmonary involvement.

Keywords: autoimmune haemolytic anemia, IgG4 associated disease, interstitial lung disease.

Published: June 1, 2020  Show citation