Vnitr Lek 2023, 69(7):416-424 | DOI: 10.36290/vnl.2023.083

Chronic critical limb ischemia (CLTI)

Miroslav Chochola
II. interní klinika kardiologie a angiologie VFN a 1. LF UK, Praha

Chronic critical limb ischemia (CLTI - chronic limb threatening ischemia) is considered the most serious type of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene, due to occlusion of peripheral arterial vessels. It is associated with a high risk of major amputations, cardiovascular events and death. Treatment of patients with CLTI places a significant economic burden on healthcare systems worldwide. An overview of the epidemiology, pathophysiology, diagnosis and treatment of CLTI is presented.

Keywords: peripheral artery disease, chronic, chronic limb­‑threatening ischemia, nonrevascularization treatments, surgical and endovascular treatment.

Accepted: October 19, 2023; Published: October 26, 2023  Show citation

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Chochola M. Chronic critical limb ischemia (CLTI). Vnitr Lek. 2023;69(7):416-424. doi: 10.36290/vnl.2023.083.
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