Vnitr Lek 2024, 70(5):289-294 | DOI: 10.36290/vnl.2024.058

Sequential antibiotic therapy

Pavel Dlouhý
Infekční oddělení Masarykovy nemocnice v Ústí nad Labem, Krajská zdravotní, a. s.

The article summarizes information on sequential antibiotic therapy, i.e. the transition from parenteral to oral administration of antibiotics. The aim of this approach is to improve patient comfort, reduce the length of hospital stay, limit complications associated with intravenous access, and decrease costs, all while achieving the same treatment outcomes as in parenteral antibiotic therapy. The review also outlines the conditions on the patient's side, suitable clinical situations, and available oral antibiotics.

Keywords: antibiotics, sequential treatment, pneumonia, endocarditis, osteomyelitis.

Accepted: August 28, 2024; Published: September 4, 2024  Show citation

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Dlouhý P. Sequential antibiotic therapy. Vnitr Lek. 2024;70(5):289-294. doi: 10.36290/vnl.2024.058.
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    References

    1. Štefan M. Délka antibiotické terapie nejčastějších bakteriálních infekcí. Vnitř Lék. 2024;70(5):284-288. Go to original source...
    2. Štefan M, Dlouhý P: OPAT - ambulantnî parenterálnî antimikrobiálnî terapie. Doporučený postup Společnosti infekčnîho lékařstvî ČLS JEP (17. 5. 2023). Available from: https://infektologie.cz/Standardy/OPAT_DP_2023_05_17-2.pdf.
    3. Barlow GD, Nathwani D. Sequential antibiotic therapy. Curr Opin Infect Dis 2000;13(6):599-607. Go to original source... Go to PubMed...
    4. Finch RG, Greenwood D, Norrby SR, Whitley RJ (Eds). Antibiotic and Chemotherapy (Ninth Edition), W.B.Saunders 2011, ISBN 9780702040641.
    5. Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):e51-e77. Go to original source... Go to PubMed...
    6. Mandell LA, Bergeron MG, Gribble MJ, et al. Sequential antibiotic therapy: Effective cost management and patient care. Can J Infect Dis. 1995;6(6):306-15. Go to original source... Go to PubMed...
    7. Beneš J. Antibiotika: systematika, vlastnosti, použití. Grada 2018, ISBN 9788027106363
    8. Gangji D, Jacobs F, de Jonckheer J, et al. Brief report: randomized study of intravenous versus sequential intravenous/oral regimen of ciprofloxacin in the treatment of gram-negative septicemia. Am J Med. 1989;87(5):S206-S208. Go to original source... Go to PubMed...
    9. Ramirez JA, Srinath L, Ahkee S, et al. Early switch from intravenous to oral cephalosporins in the treatment of hospitalized patients with community-acquired pneumonia. Arch Intern Med. 1995;155:1273-1276. Go to original source...
    10. Shalit I, Dagan R, Engelhard D, et al. Cefuroxime efficacy in pneumonia: sequential short-course IV/oral suspension therapy. Isr J med Sci. 1994;30:684-689.
    11. Bonkat G, Bartoletti R, Bruyere F, et al. EAU Guidelines on urological infections. https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urological-Infections-2024.pdf.
    12. Rieger K, Boss JA, MacVan SH, et al. Intravenous-only or intravenous transitioned to oral antimicrobial for Enterobacteriaceae-associated bacteremic urinary tract infection. Pharmacother. 2017;37:1479-1483. Go to original source... Go to PubMed...
    13. Fésüs A, Matuz M, Papfalvi E, et al. Evaluation of the diagnosis and antibiotic prescription pattern in patients hospitalized with urinary tract infections: Single-center study from a university-affiliated hospital. Antibiotics. 2023;12:1689. Go to original source... Go to PubMed...
    14. Spellberg B, Chambers HF, Musher DM, et al. Evaluation of a paradigm shift from intravenous antibiotics to oral step-down therapy for the treatment of infective endocarditis: A narrative review. AMA Intern Med. 2020;180(5):769-777. Go to original source... Go to PubMed...
    15. Iversen K, Ihlemann N, Gill SU et al. Partial oral versus intravenous antibiotic treatment of endocarditis. N Engl J Med. 2019;380:415-24. Go to original source... Go to PubMed...
    16. Pries-Heje MM, Hjulmand JG, Lenz IT, et al. Clinical implementation of partial oral treatment in infective endocarditis: the Danish POETry study. Eur Heart J 2023;44(48):5095-5106. Go to original source... Go to PubMed...
    17. Mzabi A, Kerneis S, Richaud C, et al. Switch to oral antibiotics in the treatment of infective endocarditis is not associated with increased risk of mortality in non-severely ill patients. Clin Microbiol Infect. 2016;22:607-12. Go to original source... Go to PubMed...
    18. Brown A, Jefferson HL, Daley P, et al. Partial oral versus full intravenous antibiotic treatment of endokarditis in people who inject drugs: A systematic review. Assoc Med Microbiol Infect Dis Can. 2024;8(4):253-261. Go to original source... Go to PubMed...
    19. Parker RH, Fossieck BE. Intravenous followed by oral antimicrobial therapy for staphylococcal endocarditis. Ann Intern Med. 1980;93:832-4. Go to original source... Go to PubMed...
    20. Delgado V, Marsan AJ, deWaha S, et al. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023;44:3948-4042. Go to original source... Go to PubMed...
    21. Brown E, Gould FK. Oral antibiotics for infective endocarditis: a clinical review. J Antimicrob Chemother. 2020;75:2021-2027. Go to original source... Go to PubMed...
    22. Haddad N, Ajaz J, Mansour L, et al. A review of the clinical utilization of oral antibacterial therapy in the treatment of bone infections in adults. Antibiotics. 2024;13,4. Go to original source... Go to PubMed...
    23. Li HK, Rombach I, Zambellas R, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019;380:425-436. Go to original source... Go to PubMed...
    24. Azamgarhi T, Shah A, Warren S. Clinical experience of implementing oral versus intravenous antibiotics (OVIVA) in a specialist orthopedic hospital. Clin Infect Dis. 2021;73:e2582-e2588. Go to original source... Go to PubMed...
    25. Wald-Dickler N, Holtom PD, Phillips MC, et al. Oral is the new IV. Challenging decades of blood and bone infection dogma: A systematic review. Am J Med. 2022;135:369-379.e1. Go to original source... Go to PubMed...
    26. Gariani K, Lebowitz D, Kressmann B, et al. Oral amoxicillin-clavulanate for treating diabetic foot infections. Diabetes Obes Metab. 2019;21:1483-1486. Go to original source... Go to PubMed...
    27. Zimmerli W, Sendi P. Orthopaedic biofilm infections. APMIS 2017;125:353-364. Go to original source... Go to PubMed...
    28. Štefan M. Antibiotika v klinické praxi. Třetí, přepracované a rozšířené vydání. 344 s. Galén 2024, ISBN 978-80-7492-710-2.

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