Vnitr Lek 2025, 71(4):E22-E27 | DOI: 10.36290/vnl.2025.050
Cholestasis and Carcinoma of the Ureter: Stauffer Syndrome?
- I. interná klinika UN LP a UPJŠ LF v Košiciach
Stauffer syndrome is a rare paraneoplastic syndrome classically associated with clear cell renal carcinoma, rarely with other malignancies. It is a disease of unclear pathophysiology characterized by reversible anicteric, rarely icteric, elevation of liver enzymes, sedimentation, thrombocytosis, prolongation of activated partial thromboplastin time and hepatosplenomegaly in the absence of hepatobiliary obstruction. Therefore, it is important to consider Stauffer syndrome in the differential diagnosis for unexplained cholestasis in the absence of obstruction (e.g. metastatic) in the liver. This may allow early recognition and treatment of occult malignancy. After achieving remission, the laboratory findings are partially or completely corrected. The case report describes a patient with renal failure, autoimmune hemolytic anemia and unexplained cholestasis, which can be explained by Stauffer syndrome. Namely, the patient exited and during the autopsy, carcinoma of the ureter was found.
Keywords: Autoimmune hemolytic anemia, cholestatic hepatopathy, ureteral carcinoma, renal failure, Stauffer syndrome.
Accepted: June 3, 2025; Published: June 19, 2025 Show citation
References
- Jakse G, Madersbacher H. Stauffer's syndrome. Reversible Hepatic Dysfunction in Renal Cell Carcinoma. Wien Klin Wochenschr. 1978;90(8):268-270.
- Bedke J, Buse M, Kurosch A, et al. Paraneoplastische Syndrome des Nierenzellkarzinoms. Urologe. 2007;46:45-48.
Go to original source... 
Go to PubMed... - Elseidy SA, Awad AK, Mandal D, et al. Stauffer syndrome: A Comprehensive Review of the Disease and Diagnostic Plan Proposal. Egypt J Intern Med. 2022;34(39). Available from DOI: . Go to original source...
- Steins M, van de Loo J. Pathogenese der nephropathisch bedingten Koagulopathien. In: Onkodin.de. vom 22. Oktober 2002.
- Sharma N, Darr U, Darr A, et al. Stauffer Syndrome: A Comprehensive Review of the Icteric Variant of the Syndrome. Cureus. 2019;11(10):e6032. Available from DOI: . Go to original source... Go to PubMed...
- Al-Taee IK, Al-Safar JJ, Al-Falahi YS et al. The Clinical Significance of β-2-microglobulin in End-Stage Renal Disease. Saudi J Kidney Dis Transpl. 2003;14(4):492-496.
- Bastani B, Chu N. Serum CA-125 Level in End-stage Renal Disease Patients Maintained on Chronic Peritoneal Dialysis or Hemodialysis: The Effect of Continuous Presence of Peritoneal Fluid, Peritonitis, and Peritoneal Catheter Implantation. Am J Nephrol. 1995;15(6):468-472. Go to original source... Go to PubMed...
- Nakahama H, Tanaka Y, Fujita Y, et al. CYFRA 21-1 and ProGRP, Tumor Markers of Lung Cancer, are Elevated in Chronic Renal Failure Patients. Respirology. 19983(3):207-210. Go to original source...
- Rapellino M, Niklinski J, Pecchio F, et al. CYFRA 21-1 as a Tumour Market for Bronchogenic Carcinoma. Eur Respir J. 1995;8:407-410. Go to original source... Go to PubMed...
- Mhaber S, El Kabli A, Mourabit S, et al. An Evans Syndrome Revealing a Renal Neoplasm. JCRMH 2023; 3(8). Available from DOI: .
- Shire Canada Inc. AGRYLIN® product monograph. Saint-Laurent, Quebec; 2013.
- Kwiatkowski J, Kuliszkiewicz-Janus M, Rymer W, et al. Treatment of Essential Thrombocythemia with Anagrelide Is Associated with an Increased Risk of Worsened Kidney Function. Pharmacology. 2021;106(5-6):316-322. Go to original source... Go to PubMed...
- Weber TH, Kerttula Y. Carcinoembryonic Antigen (CEA) in Blood in Cases of Pneumonia. Scand J Infect Dis. 1986;18(6):547-550. Go to original source... Go to PubMed...
- Bast RC, Xu F-J, Yu Y-H et al. CA 125: The Past and the Future. The International Journal of Biological Markers. 1998;13(4):179-187. Available from DOI: . Go to original source... Go to PubMed...
- Lee T, Teng TZJ, Shelat VG. Carbohydrate Antigen 19-9 - Tumor Marker: Past, Present, and Future. World J Gastrointest Surg. 2020;12(12):468-490. Available from DOI: . Go to original source... Go to PubMed...
- Hogan DE Jr., Datta S, Kesar V, et al. Stauffer Syndrome: The Renal-Hepato Syndrome: 2164. Am J Gastroenterol. 2017;112:S1195. Available from WWW: . Go to original source...
- Denaro N, Garrone O, Occelli M, et al. Unusual Fatal Outcome Following Administration of a Combination of Anti-PD1 and Anti-CTLA4 in Metastatic Renal Cell Carcinoma: Liver Toxicity Case Report and a Literature Review. EJCRIM 2021; 8. Available from DOI: . Go to original source... Go to PubMed...