Natriuretické peptidy, porucha funkce ledvin a vznik kardiovaskulárních komplikací - editorial

R. Pudil, M. Tichý

Vnitr Lek 2009, 55(10):913-914  

IgA pemfigus provázející mnohočetný myelom - editorial

K. Veselý

Vnitr Lek 2009, 55(10):915-916  

Characteristics of foot ulcers in diabetic patients

L. Štrbová, B. Krahulec, I. Waczulíková, Ľ. Gašpar, E. Ambrózy

Vnitr Lek 2009, 55(10):918-924  

Introduction: Diabetic foot syndrome is often presented as a skin lesion in diabetics. The aim of our study was to analyse foot ulcerations in diabetics, together with ethiopatogenesis, location and grade of impairment. Methods: We analysed foot ulcerations in 124 diabetics who attended outpatient foot clinic, or were hospitalized in the period from 1996 to 2006. Basic neuropathy screening examination was made with cotton wisp, pin-prick, tuning fork, and monofilament. Beside the evaluation of the presence of pedal pulses, the ankle-brachial pressure index was measured. If the infection of foot ulceration was present, bacteriology examinations was...

Neuropeptide Y, ghrelin and leptin plasma levels in anorexia nervosa patients and their changes during six-week refeeding

L. Beranová, D. Sedláčková, J. Kopečková, V. Hainer, H. Papežová, H. Kvasničková, J. Nedvídková

Vnitr Lek 2009, 55(10):925-928  

Objective:Anorexia nervosa (AN) is characterized by markedly changes in hormone secretion influencing food intake, energy homeostasis and long-term body weight regulation. The aim of this study was to determine neuropeptide Y (NPY), ghrelin and leptin plasma levels and their changes after six weeks of nutritional-rehabilitation program in severely malnourished anorexia nervosa patients. Methods: Ten women with DSM-IV diagnosed anorexia nervosa, hospitalized (BMI 14.74 ± 0.43; age 23.3 ± 1.0) and ten age-matched healthy women (BMI 21.45 ± 0.72; age 24.3 ± 0.8) were enrolled to the study. Fasting plasma levels of...

Secondary dyslipidaemia after oral contraceptives

V. Soška, J. Fiala, K. Nebeská, D. Hrubá

Vnitr Lek 2009, 55(10):929-933  

The aim of the study:To examine changes to blood lipid and lipoprotein levels following introduction of modern oral hormonal contraception agents and to evaluate atherogenic character of this dyslipidemia. Methods, patient sample: Forty four women of the mean age of 22.7 ± 3.5 years, BMI 21.4 ± 2.5 kg/sqm, waste line 71.9 ± 7.1 cm and BP 115.7 ± 12.2/70.1 ± 8.3 mm Hg were included. Total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, apolipoprotein A1 and apolipoprotein B levels were assessed before the introduction of contraception and 3 months into the treatment. Results: Following 3 months...

BNP and echocardiographic parameters in patients with chronic kidney disease and dialyzed patients

I. Valočiková, G. Valočik, B. Krištofová, Ľ. Družbacká, R. Roland, P. Mitro

Vnitr Lek 2009, 55(10):934-939  

We assessed the relation between BNP levels and some echocardiographic parameters of systolic and diastolic function of the left ventricle in 49 patients (mean age 69.39 ± 8.47 years) with chronic kidney disease in different stages of chronic renal failure according to K/DOQI and in 45 subjects (mean age 52.6 ± 14.85 years) on dialysis. Median for BNP in the group of patients with chronic renal failure was 132 pg/ml, and in dialysis subjects 320 pg/ml. None of our patients had clinical signs of heart failure during the last six months. Using a method of correlation matrix we found the left ventricular mass and its indexed value as a common...

Relationship between quality of life and BODE index of stable ex-smokers with chronic obstructive pulmonary disease

V. Koblížek, F. Salajka, E. Čermáková, M. Tomšová, D. Pohnětalová, P. Papoušek, V. Bartoš, T. Dobešová, Z. Paráková, J. Ruta, V. Sedlák

Vnitr Lek 2009, 55(10):940-947  

Background and aim:This study was carried out to assess relationship between quality of life (QoL) and disease severity expressed by multifactorial prognostic index (BODE) in ex-smokers suffering from chronic obstructive pulmonary disease (COPD), minimally 8 weeks free of exacerbation. Materials and methods: The evaluation was performed in 98 randomly recruited COPD patients enrolled into a cross-sectional, observational CILIARY study at the Department of Pneumology, Charles University, Faculty of Medicine in Hradec Králové. In them, quality of life evaluation using the SGRQ questionnaire and the BODE index calculation was performed. We...

Gastroesophageal reflux disease. Standards of the Czech society of gastroenterology - actualization 2009

K. Lukáš, J. Bureš, V. Drahoňovský, A. Hep, V. Jirásek, V. Mandys, J. Martínek, P. Richter, A. Štrosová

Vnitr Lek 2009, 55(10):967-975  

Presently, gastroesophageal reflux disease is defined as a disorder where reflux of the stomach content is bothersome and/or brings about complications. The state when macroscopically detectable erosions of mucosa are present is known as erosive reflux disease and the term non-erosive reflux disease is used for the condition with no macroscopic erosions. Reflux oesophagitis is a frequent sign of the disease. A condition, where reflux symptoms persist or new occur and oesophagitis healing fails to take place despite maximum treatment, is classified as refractory gastroesophageal reflux disease. The main symptoms of gastroesophageal reflux disease include...

Therapy of the gastroesophageal reflux disease - state of the art

K. Lukáš, A. Žák

Vnitr Lek 2009, 55(10):949-954  

Gastroesophageal reflux disease is defined as a disorder where reflux of the stomach content is bothersome and/or brings about complications. A condition, where reflux symptoms persist or new occur and oesophagitis healing fails to take place despite maximum treatment, is classified as refractory gastroesophageal reflux disease. A motility disorder rather than acid hypersecretion is the most important cause of gastroesophageal reflux disease. Prokinetic agents are thus the most logical treatment choice for gastroesophageal reflux disease, although proton pump inhibitors or, alternatively, a combination of these two therapeutic groups are the most effective.

Head-up tilt test - do we really know all about it?

J. Plášek, V. Doupal, Z. Hrabovská

Vnitr Lek 2009, 55(10):955-960  

Head-up tilt test (HUTT) falls within the competence of functional cardiological examination. Most often it is being used for the diagnostical approach to possibly neurally-mediated syncope, less is known about the possibility of using tilt table test in the treatment of vasovagal syncope. The main goal of this article is to make clear the principles, appropriate indication, performance and subsumption of HUTT in the algorithm of syncope investigation. Moreover it will be marginally mentioned how HUTT can be used in predicting cardiovascular risk of patients with coronary artery disease.

Gastric neuroendocrine tumors

O. Louthan

Vnitr Lek 2009, 55(10):961-966  

The aim of the article is to present the state-of-the art in terms of diagnosis and therapy of these rare, usually biologically inactive neuroendocrine tumors, being classified into three main types. They differ from each other according to the conditions of their origin, biological properties and management. Recent classification according to WHO and ENETS (European Neuroendocrine Tumor Society) and proposal of TNM classification are presented. Diagnostic methods and therapeutical procedures, including experimental approaches, are outlined.

Skin adverse effects of amiodarone

S. Zgažarová, H. Jedličková, V. Vašků

Vnitr Lek 2009, 55(10):976-980  

Background:Amiodarone has belonged to frequently used antiarrhythmic in the treatment of supraventricular and ventricular tachyarrhytmias since the sixties of the twentieth century. Amiodarone is a chemically iodinated benzofuran derivative with mono-N-desethylamiodarone as its major metabolite. Objective: This review is focused on numerous adverse reactions. The incidence of amiodarone induced side-effects ranges from 16-98% of patients receiving amiodarone and it appears to be dose related. Case reports: We describe three cases of hyperpigmentation after using amiodarone in elder men. Conclusion: Skin side effects are common, they usually...

IgA pemphigus accompanying multiple myeloma has disappeared following the treatment with bortezomib (Velcade), cyclophosphamide and dexamethasone. Case study and literature review

Z. Adam, J. Feit, M. Krejčí, L. Pour, V. Vašků, Z. Čermáková, J. Mayer, R. Hájek

Vnitr Lek 2009, 55(10):981-990  

IgA pemphigus, resembling subcorneal pustulous dermatosis, represents a rare complication of IgA type monoclonal gammopathy. The patient dates the onset of initial symptoms of vesicular-bullous disease to 1990. She was first examined at our clinic in 2001 with the following conclusion "type IgA monoclonal gammopathy of unknown significance". The first immunosuppressive treatment of vesicular-bullous disorder was administered in 2003 (dexamethasone 20 mg on days 1-4 and 15-18 in monthly cycles + daily cyclophosphamide 50 mg). Cyclophosphamide was administered for 6 months in total and dexamethasone for further 3 months. During the treatment, intensity...

24-year old male with febricity, multi-organ dysfunction and fast progressing ARDS

J. Chvojka, A. Kroužecký, J. Raděj, R. Sýkora, T. Karvunidis, I. Novák, M. Matějovič

Vnitr Lek 2009, 55(10):991-994  

A 24-year-old man presented with cough, sore throat, fever, maculopapulous exanthema, pericardial and pleural effusion. Despite extensive evaluation neither infectious, autoimmune, hematological nor oncological disorders were revealed. Broad spectrum antibiotic and subsequently corticosteroid treatment failed to resolve the symptoms. Multiorgan failure with rapid progress of acute respiratory distress syndrome and circulatory failure developed and patient died. Adult onset Still's disease (AOSD), a diagnosis considered in this patient, is a rare disease with unknown prevalence, pathogenesis and etiology. Clinically it is characterized by spiking fever,...

Kopřiva F et al. Neurogenní zánět. Praha: Maxdorf Jessenius 2009. 244 stran. ISBN 978-80-7345-174-5

Jindřich Lokaj

Vnitr Lek 2009, 55(10):1004  

Prim. MUDr. Jiří Spáčil, CSc., sedmdesátiletý

Štěpán Svačina

Vnitr Lek 2009, 55(10):1003  

Cielené vysvetľovanie cievnych chorôb a cievnych porúch

P. Gavorník

Vnitr Lek 2009, 55(10):996-997  

Sympozium firmy Abbott na XVI. kongresu České internistické společnosti ČLS J. E. Purkyně 2009

J. Špinar

Vnitr Lek 2009, 55(10):999-1002