Krátká baterie pro testování fyzické zdatnosti seniorů - editorial

H. Kubešová Matějovská

Vnitr Lek 2013, 59(4):241  

Dálková monitorace implantabilních přístrojů v kardiologii - editorial

M. Sepši

Vnitr Lek 2013, 59(4):242-243  

Aortální stenóza - editorial

J. Popelová

Vnitr Lek 2013, 59(4):244-245  

Aortální stenóza - editorial

R. Čerbák

Vnitr Lek 2013, 59(4):246-248  

Changes in weight and diabetes compensation (HbA_1c) in patients with diabetes mellitus type 2 after adding exenatide (Byetta) to the current treatment in 28 diabetology departments in the Czech Republic - BIBY-II study (observations lasting 24 months)

J. Perušičová, P. Piťhová, I. Haladová, D. Ácsová, J. Bělobrádková, A. Belzová, K. Berková, B. Doležalová, H. Dvořáková, K. Hejnicová, M. Hudcová, D. Kallmünzerová, Z. Krejsová, G. Markofová, H. Müllerová, K. Owen, M. Pelikánová, L. Raclavská, E. Račická, O. Škarpová, A. Váchová, A. Veselá, J. Vyoralová, J. Brož, T. Edelsberger, M. Honka, T. Hrdina, P. Chmura, J. Tošovský

Vnitr Lek 2013, 59(4):249-255  

BIBY-II study objective:To obtain experience with long-term (24 months) exenatide treatment (Byetta) in patients with diabetes mellitus type 2 from a common clinical practice of diabetology departments in the Czech Republic. Type of observation:Observational study conducted by a randomly selected group of outpatient medical practitioners from 28 diabetology departments in the Czech Republic. Observed and assessed population:From the original population of 465 patients, who underwent a minimum of three month's Byetta treatment, 169 patients (36.6%) remained during the second prolonged observation after 18 months,...

The "Short Physical Performance Battery" in the Czech Republic - the pilot and validation study in older persons

M. Berková, E. Topinková, P. Mádlová, J. Klán, M. Vlachová, J. Běláček

Vnitr Lek 2013, 59(4):256-263  

Introduction:Population ageing increases number of seniors with decline of physical capabilities and functional deficits. Targeted interventions to maintain or increase physical performance are most effective before the development of full frailty, in so-called "pre-frail" period. One of the assessment tools for evaluation of the physical performance and/or frailty in older persons is the "Short Physical Performance Battery" - SPPB. The aim of the study was to introduce the assessment battery to clinical practice in the CR and to evaluate its selected psychometric properties. Method:Original English SPPB was translated into...

Which first-degree relatives of patients with colorectal neoplasias are at the highest risk

I. Mikoviny Kajzrlíková, P. Vítek, J. Chalupa, P. Dítě

Vnitr Lek 2013, 59(4):264-268  

Background and aims:The first-degree relatives of patients with colorectal neoplasias have higher risk of colorectal cancer than general population. The aim of our study was to identify first-degree relatives at the highest risk of colorectal neoplasia considering both their hereditary and non-hereditary risks. Methods:We have analysed the results of colonoscopic examinations of the first-degree relatives done within the project and we have compared them with the epidemiologic data relevant to colorectal cancer that we obtained from first-degree relatives. Results:160 first-degree relatives (66 men, 94 women,...

The benefits of a remote monitoring system in long-term follow up of patients with implantable cardioverter-defibrillators

O. Ošmera, A. Bulava

Vnitr Lek 2013, 59(4):269-276  

Introduction:An increasing number of patients with implantable devices in cardiology raises the need for better and more efficient outpatient follow-up. Telemonitoring (remote monitoring) can be widely used as an important part of care for the patient and the device itself due to the technological progress in communication and transmission systems and implantable devices themselves. Objectives:To evaluate the benefits of continuous remote monitoring system using Home Monitoring (HM)^TM (BIOTRONIK) compared with standard outpatient controls. Patients and methods:198 patients (67 ± 12 years, 80.8...

Aortic stenosis

P. Gregor, H. Línková

Vnitr Lek 2013, 59(4):277-283  

This paper focuses on aortic stenosis. It covers findings related to etiopathogenesis, clinical picture, echocardiographic and catheter examination. It analyses the treatment criteria with focus on the criteria of treatment by means of cardiac surgery.

Tuberculosis in the Czech Republic. Current status. Diagnosis, treatment and prevention

M. Vašáková

Vnitr Lek 2013, 59(4):284-289  

Despite the fact that the tuberculosis (TB) agent, Mycobacterium tuberculosis, was discovered more than a century ago and we have had a basic drug line for the treatment of this disease available for over 50 years, TB is still a worldwide threat, be it considering the number of the infected, or their mortality. The epidemiologic seriousness of this disease lies, however, in the chronic course of the illness, the length of time necessary for its treatment, unavailable preventative measures and the treatment in those parts of world that are stricken by hunger and poverty. The situation concerning TB in the Czech Republic (CR) is much more optimistic;...

Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form

J. Václavík

Vnitr Lek 2013, 59(4):290-294  

Perindopril is a long acting ACE inhibitor with a 24-hour lasting effect. Its positive effect on a reduction in cardiovascular events has been confirmed in a range of large randomized clinical trials and in a wide spectrum of patients: hypertonic patients, diabetics, patients with stable ischaemic heart disease, elderly patients, or patients who have undergone a cerebrovascular accident. The extending range of various fixed combinations as well as new pharmaceutical dosage forms, including the newly introduced orodispersible tablets of perindopril, enables optimization of treatment for every patient, an increase in the patient's treatment adherence,...

Oxidative stress in patients after kidney transplantation

J. Vostálová, A. Galandáková, P. Štrebl, J. Zadražil

Vnitr Lek 2013, 59(4):296-300  

Successfull kidney transplantation (KT) leads not only to normalization of renal excretory function, but also to modification of the metabolic and endocrine kidney function. The most common cause of morbidity and mortality in patients after KT are cardiovascular diseases which development is also associated with oxidative stress (OS). KT and the post-transplantation period are associated with increased OS that could gradually decrease. Some immunosuppressive drugs also contribute to increase of OS, especially compounds from a group of calcineurin inhibitors and thus indirectly contribute to increased risk of cardiovascular complications.

PET-CT documented fast onset of treatment response to cyclophosphamide, thalidomide and dexamethasone in patients with multicentric Castleman's disease. Case description and treatment information overview

Z. Adam, P. Szturz, L. Křen, M. Krejčí, L. Pour, T. Svoboda, I. Hanke, I. Penka, R. Koukalová, Z. Řehák, I. Červinková, T. Štorková, Z. Král, J. Mayer

Vnitr Lek 2013, 59(4):301-312  

Castleman's disease (also called angiofollicular lymph node hyperplasia) can take two forms with different prognosis: the localized form can usually be treated by a surgical intervention and has therefore a favourable prognosis. On the other hand, the multicentric form has an unfavourable prognosis and requires systemic treatment. Classic manifestations of multicentric Castleman's disease are multiple sites of lymphadenopathy, sometimes hepatomegaly and also splenomegaly or serous cavity effusions. Typical pathological laboratory levels measured in patients with this disease include an increased CRP level, anaemia of chronic diseases, and many patients...

Case history acquired haemophilia A

Z. Čermáková, R. Hrdličková, Š. Blahutová, A. Ligová

Vnitr Lek 2013, 59(4):313-316  

Acquired haemophilia A is a rare form of acquired coagulopathy caused by autoantibodies against coagulation factor VIII. It is characterized by major bleeding complications often life-threatening. An estimated incidence is about 1-2 cases per million inhabitants per year. The authors report case history of acquired haemophilia in 85 year old woman. Bleeding complications were well controled by bypassing agents. Inhibitor eradication was successful after the use of second line agent rituximab.

Lung metastases as the first manifestations of occult medullary microcarcinoma

J. Mačák, J. Dvořáčková, J. Mačáková, P. Vlček

Vnitr Lek 2013, 59(4):317-320  

The article is concerned with medullary microcarcinoma of the thyroid. Similarly to medullary macrocarcinoma, this may metastasize to distant sites. Reported is a case of a 54-year-old male who had suffered from chest tightness and dry irritating cough. Chest X-ray showed small nodules with poorly-defined borders of unknown etiology. Lung biopsy was performed, which detected amyloid-rich neuroendocrine carcinoma. Examination of the thyroid was recommended to confirm or rule out suspected medullary carcinoma. The biopsy examination also suggested G1 and G2 primary neuroendocrine carcinoma of the lung or diffuse idiopathic pulmonary neuroendocrine cell...

Use of vildagliptin from an internal disease specialist's point of view

R. Kožnarová

Vnitr Lek 2013, 59(4):322-324  

Dipeptidyl peptidase 4 inhibitors (DPP-4) are used as an oral hypoglycaemic agent in Type-2 diabetic patients. From a clinical point of view the most important advantages of this preparation are improved diabetes compensation, significant reduction of hypoglycaemia risk compared with sulfonylurea derivatives, neutral weight profile and good GIT tolerance. Vildagliptin is a molecule from the group of DPP-4 inhibitors which is recently used in internal outpatient care.

XXXII. dny mladých internistů. Olomouc, 30.- 31. 5. 2013. Sborník abstrakt

Vnitr Lek 2013, 59(4)