[History of heart transplantation--short commentary].

J Cerný

Vnitr Lek 2000, 46(11):741-742

[Do we know when to examine the thyroid gland?].

Z Límanová

Vnitr Lek 2000, 46(11):743-744

["Non-cardiac" surgery in patients after heart transplantation].

J Fabián, E Goncalvesová, J Stencl

Vnitr Lek 2000, 46(11):745-749

UNLABELLED: Aim of the study are description and analysis of the frequency, spectrum and results of "non cardiac" surgery after heart transplantation (HTx).PATIENTS: Up to December 1999, 74 patients (9 females) of age 18-65 years (median 49) were followed-up from 1 to 144 months (median 35) after heart transplantation (HTx).RESULTS: In 10 patients 12 symptomatic non cardiac diseases require surgical procedures. Four had cholecystolithiasis, one patient cholecystolithiasis with choledocholithiasis. The rest of them suffered from renal artery occlusion, carcinoma of the cervix uteri, umbilical hernia, ileus, sigmoidal carcinoma and two from benign...

[Transplantation of the heart--indications, complications, therapy--our experience from investigations of 100 patients after cardiac transplantation].

J Krejcí, P Hude, L Spinarová, J Toman, J Cerný, P Nemec, M Frélich, A Sirotková

Vnitr Lek 2000, 46(11):750-755

Transplantation of the heart has become an accepted method for the treatment of terminal cardiac failure. Despite obvious advances in the care of patients after trasplantation a number of problems exist. The authors summarize their experience with the long-term follow-up of 100 adult patients with transplantations made in the Brno Centre of Cardiovascular and Transplantation Surgery. One-year survival in the group of patients is 80%, three-year survival 69%. The authors discuss indications and contraindications of cardiac transplantations, necessary preoperative and postoperative examinations, they follow-up the most serious complications during the...

[Epidemiological profile of thyroid volume and disorders in Slovakia].

M Tajtáková, P Langer, G Fodor, E Hanzen, Z Putz, L Kosťálová, J Michálek, A Kreze, I Klimes, E Seböková

Vnitr Lek 2000, 46(11):756-763

UNLABELLED: After 45 years of successful iodine prophylaxis a total of 6324 subject aged 7 to 70 years from East (72.0%), Central (16.2%) and West Slovakia (11.8%) were examined. The thyroid volume (ThV) by ultrasound was examined in a total of 6045 subjects. Serum level of thyrotropin (TSH) was estimated in 1919 (30.3%) and anti-thyroperoxidase antibodies (anti-TPO) in 2589 (40.9%) subjects. Iodine was estimated in 1983 (31.3%) spot urine samples. The median and 75th percentile of ThV were increasing (respectively) from 3.9 and 5.2 ml (10 yr), 8.2 and 10.2 ml (17 yr), 12.4 and 16.3 ml (31-40 yr) up to 14.1 and 19.9 ml (61-70 yr). The frequency of...

[Nitrate contaminated drinking water from private wells has an impact on the size and functional state of the thyroid gland in schoolchildren].

M Tajtáková, P Langer, Z Semanová, Z Tomková, E Szökeová, J Majoros, J Petrovicová, E Veselíny

Vnitr Lek 2000, 46(11):764-767

UNLABELLED: The authors compared the size of the thyroid gland, assessed by ultrasonographic examination of its volume and the functional state of the thyroid by examination of the serum level of TSH and anti-TPO antibodies in 492 pupils aged 10 and 13 years in two close agricultural areas. The areas differed above all as to the nitrate content of drinking water. In communities where the source of drinking water were private wells (nitrate area), as much as 68.1% of the water samples had a nitrate content > 50 mg/l and 46.4% samples > 100 mg/l. In communities where the source of drinking water was a water main with a known source (control area)...

[Damage of left ventricular function after treatment with doxorubicin in patients with malignant lymphomas].

L Elbl, V Chaloupka, I Vásová, S Nehyba, J Vorlícek, M Navrátil, I Kiss, M Cíhalová

Vnitr Lek 2000, 46(11):768-775

The authors evaluated using clinical and echocardiographic examination the effect of chemotherapy involving bolus administration of doxorubicin on the heart muscle in 90 patients with non-Hodgkin lymphoma and with Hodgkin lymphoma. In 18% of patients they found an asymptomatic decrease of the left ventricular ejection fraction during chemotherapy, chronic cardiotoxicity was recorded in 5% patients, in 2% of the patients one year after termination of chemotherapy a clinically latent myocardial infarction was found. The diastolic function was impaired (impaired relaxation) in 44% patients after terminated chemotherapy and in 50% after one year. Echocardiographic...

[The role of cholesterol and intermediary metabolites of its synthesis in intensive care and parenteral nutrition].

Z Zadák, R Hyspler, B Bakalár, S Crhová

Vnitr Lek 2000, 46(11):776-781

Hypocholesterolaemia is a frequent and typical phenomenon of many acute situations such as injury, severe infection associated with sepsis and septic shock, catabolic situations after serious operations, in myocardial infarction and neoplastic diseases. This phenomenon cannot be explained only by malnutrition or energy deficiency although they may participate in the development of hypocholesterolaemia. In the development of the mentioned acute conditions participates according to our opinion also impaired synthesis of cholesterol as well as of intermediary metabolites of its biosynthesis (isoprene, squalene, lanosterol, and lathosterol). Evidence was...

[Dyspeptic complaints in diabetic patients].

A Hep, J Dolina, J Prásek, P Dítě

Vnitr Lek 2000, 46(11):782-784

Diabetes is a frequent metabolic disease which affects also the digestive tract. Functional disorders of the latter have a negative impact on the stabilization of diabetes. An important factor as regards motility is the blood sugar level. Subjective complaints of the patients frequently do not correlate with the objectively assessed functional state of the digestive tract. The authors remind of contemporary available diagnostic and therapeutic possibilities.

[Will transplantation of peripheral blood stem haematopoietic cells definitively replace bone marrow transplantation?].

J Mayer

Vnitr Lek 2000, 46(11):785-793

Findings assembled for a long time, practically from the end of the Second World War along with modern technology of genetic engineering which brought mass production of growth factors led at the beginning of the nineties of the 20th century to a rapid rise of transplantations of peripheral stem cells. Without exaggeration it may be said that the last decade of the 20th century is the decade of transplantations of peripheral stem cells. Peripheral stem cells comprise a wide range of haematopoietic cells incl. stem cells which are after a stimulus (antitumour chemotherapy or growth factors) released from bone marrow in high concentrations into the peripheral...

[The role of cytokines in peritoneal dialysis].

S Opatrná, O Topolcan, K Opatrný

Vnitr Lek 2000, 46(11):794-800

Peritoneal dialysis is a method of renal replacement therapy which has been increasingly in use worldwide and, in recent years, also in our country. A factor limiting long-term use of peritoneal dialysis is the maintenance of the function of the peritoneum as a dialysis membrane. Impairment of the anatomical and functional integrity of the peritoneal membrane may be due to severe or recurrent peritonitis but, also, in patients without a history of peritoneal infection, presumably as a result of contact between the peritoneum and a bioincompatible dialysis solution. When investigating the structural and functional changes in the peritoneal membrane,...

[Myocarditis].

P Gregor

Vnitr Lek 2000, 46(11):801-807

In the submitted paper the author summarizes findings concerning the controversial disease of contemporary cardiology--myocarditis. The prevalence of myocarditis in post-mortem material is about 1%. It is usually of viral origin (in particular Coxsackie viruses group B). The origin can be however also bacterial, spirochetal, mycoplasmatic, mycotic, protozoan and helminthic. Clinically it is manifested by a wide spectrum of manifestations from subclinical forms to fatal conditions (cardiac failure to cardiogenic shock, arrhythmia). On the ECG it is usually manifested by changes of the repolarization stage ST-T, by impaired conduction, possibly by pathological...

[Mystery of mydriatic pupils].

J Stefánek, J Dufincová, P Vychytil, S Holmes

Vnitr Lek 2000, 46(11):808-810

The authors describe the case of a 27-year-old man who was examined on account of vertigo and blurred vision. In the objective case-history there was mild confusion, in the physical examination broad symmetrical mydriasis dominated. Later other similar patients were found. Atropine intoxication was proved. The source of the alkaloid was poppy seed contaminated with seeds of henbane (Hyoscyamus niger), in bakery goods served in the works canteen.

[Advance in therapy Parkinson's disease].

J Roth, E Růzicka, P Kanovský

Vnitr Lek 2000, 46(11):811-816