Vnitr Lek 2017, 63(7-8):465-470 | DOI: 10.36290/vnl.2017.097

History and presence of hepatitis B and C therapy

Petr Husa sr
Klinika infekčních chorob LF MU a FN Brno, pracoviště Bohunice

Infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) are the world's major causes of chronic liver disease. Care of patients infected with HBV and HCV and/or over the last 20 years has significantly improved thanks to the better understanding of the pathophysiology of disease, improvement of diagnostic, therapeutic and preventive options. The goal of treatment of chronic hepatitis B is to extend the length of life and improve its quality through the barriers of the progression of chronic hepatitis to cirrhosis, decompensation cirrhosis and hepatocellular carcinoma (HCC). Chronic HBV infection can by currently treated either with tenofovir or entecavir orally (absolute majority of cases), and that in the long-term (years), or even for life-long therapy, or with pegylated interferon α-2a, which is given by injection once a week for 48 weeks (limited possibility of use). The primary goal of chronic hepatitis C treatment is to cure the infection, by achieving a sustained virological response defined as undetectable virus nucleic acid (HCV RNA) in peripheral blood 12 or 24 weeks after the end of therapy. At present, IFN-free regimens become the standard of chronic HCV therapy with the efficiency of 95-100 % and with minimum of side effects and contraindications.

Keywords: chronic hepatitis B; chronic hepatitis C; IFN-free therapy

Received: March 6, 2017; Accepted: May 20, 2017; Published: July 1, 2017  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Husa P. History and presence of hepatitis B and C therapy. Vnitr Lek. 2017;63(7-8):465-470. doi: 10.36290/vnl.2017.097.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. World Health Organization. Guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Updated version April 2016. Dostupné z WWW: <http://www.who.int/hiv/topics/hepatitis/en>.
    2. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of chronic hepatitis B. J Hepatol 2012; 57(1): 167-185. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2012.02.010>. Go to original source... Go to PubMed...
    3. Brouwer WP. Tenofovir alafenamide for hepatitis B: evolution or revolution? Lancet Gastroenterol Hepatol 2016;1(3):174-175. Dostupné z DOI: <http://dx.doi.org/10.1016/S2468-1253(16)30083-8>. Dostupné z WWW: <http://www.thelancet.com/gastrohep>. Go to original source... Go to PubMed...
    4. European Association for the Study of Liver. EASL recommendations on treatment of hepatitis C 2015. Summary. Dostupné z WWW: <http://www.easl.eu/medias/cpg/HCV2016/Summary.pdf>[3.3.3017].
    5. AASLD recommendation for testing, managing, and treating hepatitis C. Dostupné z WWW: <http://www.hcvguidelines.org>.[3.3.2017].
    6. Foster GR et al. Sofosbuvir and velpatasvir for HCV genotype 2 and 3. N Engl J Med 2015; 373(27): 2608-2617. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1512612>. Go to original source... Go to PubMed...
    7. Pawlotsky JM. Hepatitis C virus resistance to Direct-Acting Antiviral drugs in interferon-free regimens. Gastroenterology 2016; 151(1): 70-86. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2016.04.003>. Go to original source... Go to PubMed...
    8. University of Liverpool. Drug interactions charts. Dostupné z WWW: <http://www.hep-druginteractions.org>.
    9. HARVONI. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/003850/WC500177995.pdf>.[15.8.2016].
    10. SOVALDI. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/002798/WC500160597.pdf>.[15.8.2016].
    11. EPCLUSA. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/004210/WC500211151.pdf>.[15.8.2016].
    12. VIEKIRAX. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/003839/WC500183997.pdf>.[15.8.2016].
    13. EXVIERA. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/003837/WC500182233.pdf>.[15.8.2016].
    14. Urbánek P. Exviera, Viekirax. Gastroent Hepatol 2015; 69(1): 75-80. Dostupné z DOI: <http://dx.doi.org/10.14735/amgh201575>. Go to original source...
    15. ZEPATIER. Souhrn údajů o přípravku. Dostupné z WWW: <http://www.ema.europa.eu/docs/cs_CZ/document_library/EPAR_-_Product_Information/human/004126/WC500211235.pdf>.[15.8.2016].
    16. Bourliére M, Gordon SC, Ramji A et al. Sofosbuvir/velpatasvir/voxilaprevir for 12 weeks as a salvage regimen in NS5A inhibitor-experienced patients with genotype 1-6 infection: The phase 3 POLARIS-1 study. Hepatology 2016; 63(Suppl 1): 102A-103A.
    17. Jacobsson IM, Asselah T, Nahass R et al. A randomized phase 3 trial of sofosbuvir/velpatasvir/voxilaprevir for 8 weeks compared to sofosbuvir/velpatasvir for 12 weeks in DAA-naïve genotype 1-6 HCV infected patients: The POLARIS-2 study. 67th Annual meeting of AASLD, Boston, 11.-15.11. 2016. Dostupné z WWW: <http://www.natap.org/2016/AASLD/AASLD_33.htm>.
    18. Foster GR, Thompson A, Ruane PJ et al. A randomized, phase 3 trial of sofosbuvir/velpatasvir/voxilaprevir for 8 weeks and sofosbuvir/velpatasvir for 12 weeks for patients with genotype 3 HCV infection and cirrhosis: The POLARIS-3 study. Hepatology 2016; 63(Suppl 1): 135A-136A.
    19. Zeuzem S, Flamm SL, Tong M et al. A randomized, controlled, phase 3 trial of sofosbuvir/velpatasvir/voxilaprevir for 8 weeks and sofosbuvir/velpatasvir for 12 weeks in Direct-Acting Antiviral-experienced patients with genotype 1-6 HCV infection: The POLARIS-4 study. Hepatology 2016; 63(Suppl 1): 56A. Dostupné z WWW: <http://www.natap.org/2016/AASLD/AASLD_18.htm>.
    20. Zeuzem S, Feld JJ, Wang S et al. ENDURANCE-1: Efficacy and safety of 8-versus 12-week treatment with ABT-493/ABT-530 in patient with chronic HCV genotype 1 infection. Hepatology 2016; 63(Suppl 1): 132A-133A. Dostupné z WWW: <http://dx.doi.org/http://www.natap.org/2016/AASLD/AASLD_32.htm>.
    21. Kowdley KV, Colombo M, Zadeikis N et al. ENDURANCE-2: Safety and efficacy of ABT-493/ABT-530 in hepatitis C virus genotype 2-infected patients without cirrhosis, a randomized, double-blind, placebo-controlled study. Hepatology 2016; 63(Suppl 1): 39A. Dostupné z WWW: <http://www.natap.org/2016/AASLD/AASLD_14.htm>.
    22. Asselah T, Hezode C, Zadeikis N et al. ENDURANCE-4: Efficacy and safety of ABT-493/ABT-530 treatment in patients with chronic HCV genotype 4, 5, or 6 infection. Hepatology 2016; 63(Suppl 1): 63A.
    23. Wyles DL, Poordad F, Wang S et al. SURVEYOR-II, Part 3: Efficacy and safety of ABT-493/ABT-530 in patients with hepatitis C virus genotype 3 infection with prior treatment experience and/or cirrhosis. Hepatology 2016; 63(Suppl 1): 62A-63A. Dostupné z WWW: <http://www.natap.org/2016/AASLD/AASLD_20.htm>.

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.