Vnitr Lek 1991, 37(3):261-267

[The role of prostaglandins in the effect of beta-blockers on stimulated blood platelets].

R Nosáľ, V Jancinová, M Petríková

Ustav experimentálnej farmakológie SAV Bratislava.

Atenolol, a selective beta-blocker, slightly potentiates the stimulated aggregation of platelets against dose-dependence. The drug potentiates similarly stimulated release of arachidonic acid, it does not influence the formation of malondialdehyde and the thromboxane B2 production in stimulated platelets. The non-selective beta-blocker propranolol inhibits in a dose-dependent way stimulated aggregation, the release of arachidonic acid, it reduces thromboxane B2 production in stimulated platelets. The authors revealed that the anti-aggregating action of beta-blockers is closely related to their ability to influence prostaglandin synthesis in stimulated platelets.

Keywords: Adrenergic beta-Antagonists, pharmacology, ; Animals; Arachidonic Acid; Arachidonic Acids, metabolism, ; Atenolol, pharmacology, ; Blood Platelets, metabolism, ; Drug Synergism; Malondialdehyde, metabolism, ; Platelet Aggregation, drug effects, ; Platelet Aggregation Inhibitors, pharmacology, ; Propranolol, pharmacology, ; Rats; Rats, Inbred Strains; Thromboxane B2, biosynthesis,

Published: March 1, 1991  Show citation