Vnitr Lek 1991, 37(3):261-267
[The role of prostaglandins in the effect of beta-blockers on stimulated blood platelets].
- Ustav experimentálnej farmakológie SAV Bratislava.
Klíčová slova: Adrenergic beta-Antagonists, pharmacology, ; Animals; Arachidonic Acid; Arachidonic Acids, metabolism, ; Atenolol, pharmacology, ; Blood Platelets, metabolism, ; Drug Synergism; Malondialdehyde, metabolism, ; Platelet Aggregation, drug effects, ; Platelet Aggregation Inhibitors, pharmacology, ; Propranolol, pharmacology, ; Rats; Rats, Inbred Strains; Thromboxane B2, biosynthesis,
Atenolol, a selective beta-blocker, slightly potentiates the stimulated aggregation of platelets against dose-dependence. The drug potentiates similarly stimulated release of arachidonic acid, it does not influence the formation of malondialdehyde and the thromboxane B2 production in stimulated platelets. The non-selective beta-blocker propranolol inhibits in a dose-dependent way stimulated aggregation, the release of arachidonic acid, it reduces thromboxane B2 production in stimulated platelets. The authors revealed that the anti-aggregating action of beta-blockers is closely related to their ability to influence prostaglandin synthesis in stimulated platelets.
Keywords: Adrenergic beta-Antagonists /pharmacology/; Animals; Arachidonic Acid; Arachidonic Acids /metabolism/; Atenolol /pharmacology/; Blood Platelets /metabolism/; Drug Synergism; Malondialdehyde /metabolism/; Platelet Aggregation /drug effects/; Platelet Aggregation Inhibitors /pharmacology/; Propranolol /pharmacology/; Rats; Rats, Inbred Strains; Thromboxane B2 /biosynthesis/
Zveřejněno: 1. březen 1991 Zobrazit citaci