Vnitr Lek 2005, 51(2):226-230

Congenital adrenal hyperplasia, defect of 17α-hydroxylase as a rare cause of hypertension and hypocalaemia

V. Olšovská^1,*, J. Šulcová², A. Hondlová¹, H. Šiprová¹

¹ II. interní klinika Lékařské fakulty MU a FN u sv. Anny, Brno, přednosta doc. MUDr. Miroslav Souček, CSc.

² Oddělení steroidních hormonů Endokrinologického ústavu, Praha, ředitel doc. MUDr. Vojtěch Hainer, CSc.

Authors describe infrequently occurring case of congenital adrenal hyperplasia, partial defect of 17α-hydroxylase in female patient with hypertension, hypocalaemia, menstrual cycle disorders and sterility. Diagnosis was established on the basis of native examination of steroid spectrum together with both stimulation and suppression tests and CT examination. After the treatment with dexamethason was established, the blood pressure and electrolyte levels reached the correction. This report supports the importance of the whole steroid spectrum examination in the patients with this symptomatology in order to eliminate rare causes of endocrine hypertension.

Keywords: congenital adrenal hyperplasia; endocrine hypertension; hypocalaemia; defect of 17α-hydroxylase

Received: March 11, 2004; Accepted: April 14, 2004; Published: February 1, 2005  Show citation