Vnitr Lek 2017, 63(12):967-971 | DOI: 10.36290/vnl.2017.176

Drug induced tendon injury

Štefan Alušík1,*, Zoltán Paluch2
1 Katedra vnitřního lékařství IPVZ, Praha
2 Ústav farmakologie 2. LF UK, Praha

Tendon injury belongs to the less known side effects of some drugs, reported until recently only for glucocorticoids and fluoroquinolones. To date, some other classes of drugs such as statins, aromatase inhibitors, anabolic steroids, potentially causing tendon injury, have been added to the list. The authors discuss the most common clinical presentations, diagnosis, and management as well as latest experimental data regarding this issue. The most often, the Achilles tendon is affected, however, nearly every tendon of the entire body may be affected. Tendon rupture or drug induced tendinopathy should be strongly considered in those who have a tendon injury and have recently taken these drugs.

Keywords: anabolic steroids; aromatase inhibitors; fluoroquinolones; glucocorticoids; statins; tendon injury

Received: June 27, 2017; Accepted: October 1, 2017; Published: December 1, 2017  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Alušík Š, Paluch Z. Drug induced tendon injury. Vnitr Lek. 2017;63(12):967-971. doi: 10.36290/vnl.2017.176.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. FDA Drug Safety Communicatio: FDA updates warnings for oral and injectable fluorochinolone antibiotics due to disabling side effects. Dostupné z WWW: <http://www.fda.gov/Drugs/DrugSafety/ucm511530.htm>.
    2. Lee HB. Avulsion and rupture of the tendo calcaneus after injection of hydrocortisone (letter). Br Med J 1957; 2(5041): 395. Go to original source... Go to PubMed...
    3. Unverferth LJ, Olix ML. The effect of local steroid injections on tendon. J Sports Med 1973; 1(4): 31-37. Go to original source... Go to PubMed...
    4. Newnham DM, Douglas JG, Legge JS et al. Achilles tendon rupture: an underrated complication of corticosteroid treatment. Thorax 1991; 46(11): 853-854. Go to original source... Go to PubMed...
    5. Blanco I, Krähenbühl S, Schlienger RG. Corticosteroid-associated tendinopathies: an analysis of the published literature and spontaneous pharmacovigilance data. Drug Saf 2005; 28(7): 633-643. Go to original source... Go to PubMed...
    6. Omar M, Haas P, Ettinger M et al. Simultaneous bilateral quadriceps tendon rupture following long-term low-dose nasal corticosteroid application. Case Rep Orthop 2013; 2013: 657845. Dostupné z DOI: <http://dx.doi.org/10.1155/2013/657845>. Go to original source... Go to PubMed...
    7. Aydingöz U, Aydingöz O. Spontaneous rupture of the tibialis anterior tendon in a patient with psoriasis. Clin Imaging 2002; 26(3): 209-211. Go to original source... Go to PubMed...
    8. Lee SK, Ling CM. The response of human tendon to hydrocortisone injection. Singap Med J 1975; 16(4): 259-262.
    9. Poulsen RC, Carr AJ, Hulley PA. Protection against glucocorticoid-induced damage in human tenocytes by modulation of ERK, Akt and forkhead signaling. Endocrinology 2011; 152(2): 503-514. Dostupné z DOI: <http://dx.doi.org/10.1210/en.2010-1087>. Go to original source... Go to PubMed...
    10. Poulsen RC, Watts AC, Murphy RJ et al. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtusin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence. Ann Rheum Dis 2014; 73(7): 1405-1413. Dostupné z DOI: <http://dx.doi.org/10.1136/annrheumdis-2012-203146>. Go to original source... Go to PubMed...
    11. Chen W, Tang H, Zhou M et al. Dexamethasone inhibits the differentiation of rat tendon stem cells into tenocytes by targeting the scleraxis gene. J Steroid Biochem Mol Biol 2015; 152: 16-24. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jsbmb.2015.04.010>. Go to original source... Go to PubMed...
    12. Spoendlin J, Meier C, Jick SS et al. Bisphosphonate therapy start may transiently increase the risk of tendon rupture in patients with glucocorticoid co-medication: a population-based observational study. Pharmacoepidemiol Drug Saf 2016; 25(10): 1116-1123. Dostupné z DOI: <http://dx.dorg/10.1002/pds.4042>. Go to original source... Go to PubMed...
    13. Bailey RR, Kirk JA, Peddie BA. Norfloxacin-induced rheumatic disease. N Z Med J 1983; 96(736): 590. Go to PubMed...
    14. McEwan SR, Davey PG. Ciprofloxacin and tenosynovitis. Lancet 1988; 2(8616): 900. Go to original source... Go to PubMed...
    15. Khaliq Y, Zhanel GG. Fluoroquinolone-associated tendinopathy: a critical review of the literature. Clin Infect Dis 2003; 36(11): 1404-1410. Go to original source... Go to PubMed...
    16. Shimatsu K, Subramaniam S, Sim H et al. Ciprofloxacin-induced tendinopathy of the gluteal tendons. J Gen Intern Med 2014; 29(11): 1559-1562. Dostupné z DOI: <http://dx.doi.org/10.1007/s11606-014-2960-4>. Go to original source... Go to PubMed...
    17. Fraunfelder FW, Fraunfelder FT. Diplopia and fluoroquinolones. Ophthalmology 2009; 116(9): 1814-1817. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ophtha.2009.06.027>. Go to original source... Go to PubMed...
    18. Tendon disorders with ofloxacin ear drops. Prescrire Int 2016; 25(169): 72.
    19. Mafulli N, Sharma P, Luscombe KL. Achilles tendinopathy: aetiology and management. J R Soc Med 2004; 97(10): 472-476. Go to original source... Go to PubMed...
    20. Aldred KJ, Kerns RJ, Osheroff N. Mechanism of quinolone action and resistence. Biochemistry 2014; 53(10): 1565-1574. Dostupné z DOI: <http://dx.doi.org/10.1021/bi5000564>. Go to original source... Go to PubMed...
    21. Kato M, Takada S, Kashida I et al. Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats. Toxicol Pathol 1995; 23(3): 385-392. Go to original source... Go to PubMed...
    22. Shakibaei M, Stahlmann R. Ultrastructure of Achilles tendon from rats after treatment with fleroxacin. Arch Toxicol 2001; 75(2): 97-102. Go to original source... Go to PubMed...
    23. Simonin MA, Gegout-Pottie P, Minn A et al. Pefloxacin-induced Achilles tendon toxicity in rodents: biochemical changes in proteoglykan synthesis and oxidative damage to collagen. Antimicrob Agents Chemother 2000; 44(4): 867-872. Go to original source... Go to PubMed...
    24. Tsai WC, Hsu CC, Chen HC et al. Ciprofloxacin-mediated inhibition of tenocyte migration and down-regulation of focal adhesion kinase phosphorylation. Eur J Pharmacol 2009; 607(1-3): 23-26. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ejphar.2009.02.006>. Go to original source... Go to PubMed...
    25. Tsai WC, Hsu CC, Chen CP et al. Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen. J Orthop Res 2011; 29(1): 67-73. Dostupné z DOI: <http://dx.doi.org/10.1002/jor.21196>. Go to original source... Go to PubMed...
    26. Badal S, Her IF, Maher LJ. Nonantibiotic effects of fluorochinolones in mammalian cells. J Biol Chem 2015; 290(36): 22287-22297. Dostupné z DOI: <http://dx.doi.org/10.1074/jbc.M115.671222>. Go to original source... Go to PubMed...
    27. Pamar C, Meda KP. Achilles tendon rupture associated with combination therapy of levofloxacin and steroid in four patients and a review of the literature. Foot Ankle Int 2007; 28(12): 1287-1289. Dostupné z DOI: <http://dx.doi.org/10.3113/FAI.2007.1287>. Go to original source... Go to PubMed...
    28. Bidell MR, Lodise TP. Fluoroquinolone-associated tendinopathy: Does levofloxacin pose the greatest risk? Pharmacotherapy 2016; 36(6): 679-693. Dostupné z DOI: <http://dx.doi.org/10.1002/phar.1761>. Go to original source... Go to PubMed...
    29. Chazerain P, Hayem G, Hamza S et al. Four cases of tendinopathy in patients on statin therapy. Joint Bone Spine 2001; 68(5): 430-433. Go to original source... Go to PubMed...
    30. Marie I, Delafenetre H, Massy N et al. Tendinous disorders attributed to statins: A study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature. Arthritis Rheum 2008; 59(3): 367-372. Dostupné z DOI: <http://dx.doi.org/10.1002/art.23309>. Go to original source... Go to PubMed...
    31. De Oliveira LP, Vieira CP, Da Ré Guerra F et al. Statins induce biochemical changes in the Achilles tendon after chronic treatment. Toxicology 2013; 311(3): 162-168. Dostupné z DOI: <http://dx.doi.org/10.1016/j.tox.2013.06.010>. Go to original source... Go to PubMed...
    32. Kuzma-Kuzniarska M, Cornell HR, Moneke MC et al. Lovastatin-mediated changes in human tendon cells. J Cell Physiol 2015; 230(10): 2543-2551. Dostupné z DOI: <http://dx.doi.org/10.1002/jcp.25010>. Go to original source... Go to PubMed...
    33. Teichtahl AJ, Brady SR, Urguhart DM et al. Statins and tendinopathy: a systematic review. Med J Aust 2016; 204(3): 115-121. Go to original source... Go to PubMed...
    34. Contractor T, Beri A, Gardiner JC et al. Is statin use associated with tendon rupture? A population-based retrospective cohort analysis. Am J Ther 2015; 22(5): 337-381. Dostupné z DOI: <http://dx.doi.org/10.1097/MJT.0000000000000039>. Go to original source... Go to PubMed...
    35. Lombard JM, Zdenkowski N, Wells K et al. Aromatase inhibitor induced musculosceletal syndrome: a significant problem with limited treatment options. Support Care Cancer 2016; 24(5): 2139-2146. Dostupné z DOI: <http://dx.doi.org/10.1007/s00520-015-3001-5>. Go to original source... Go to PubMed...
    36. Nirawath P. Aromatase inhibitor-induced arthralgia: a review. Ann Oncol 2013; 24(6): 1443-1449. Dostupné z DOI: <http://dx.doi.org/10.1093/annonc/mdt037>. Go to original source... Go to PubMed...
    37. Singer O, Cigler T, Moore AB et al. Defining the aromatase inhibitor musculosceletal syndrome: a prospective study. Arthritis Care Res (Hoboken) 2012; 64(12): 1910-1918. Dostupné z DOI: <http://dx.doi.org/10.1002/acr.21756>. Go to original source... Go to PubMed...
    38. Lintermans A, Laenen A, Van Calster B et al. Prospective study to assess fluid accumulation and tenosynovial changes in the aromatase inhibitor-induced musculosceletal syndrome: 2-year follow-up data. Ann Oncol 2013; 24(2): 350-355. Dostupné z DOI: <http://dx.doi.org/10.1093/annonc/mds290>. Go to original source... Go to PubMed...
    39. Laroche M, Seniow M, Rahé H et al. Arthralgia associated with autoimmune abnormalities under aromatase inhibitor therapy: Outcome after cessation of treatment. J Rheumatol 2016; 43(10): 1945-1946. Go to original source... Go to PubMed...
    40. Kirchgesner T, Larbi A, Omoumi P et al. Drug-induced tendinopathy: from physiology to clinical applications. Joint Bone Spine 2014; 81(6): 485-492. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jbspin.2014.03.022>. Go to original source... Go to PubMed...
    41. Michna H. Tendon injuries induced by exercise and anabolic steroids in experimental mice. Int Orthop 1987; 11(2): 157-162. Go to original source... Go to PubMed...
    42. Kanayama G, DeLuca J, Meehan WP et al. Ruptured tendons in anabolic-androgenic steroid users: A cros sectional cohort study. Am J Sport Med 2015; 43(11): 2638-2644. Dostupné z DOI: <http://dx.doi.org/10.1177/0363546515602010>. Go to original source... Go to PubMed...
    43. Bottomley J, Cunliffe WJ. Acute Achilles tendonitis following oral isotretinoid therapy for acne vulgaris. Clin Exp Dermatol 1992; 17(4): 250-251. Go to original source... Go to PubMed...
    44. Rodrigues IH, Allegue F. Achilles and suprapatellar tendinitis due to isotretinoin. J Rheumatol 1995; 22(10): 2009-2010.
    45. Semira F, Wafai ZA, Khan U et al. Achilles tendinopathy as a rare adverse effect of oral isotretinoid treatment: two cases. IJGMP 2014; 3(4): 11-14.
    46. Kalden JR, Schattenkirchner M, Sörensen H et al. The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: A five-year followup study. Arth Rheum 2003; 48(6): 1513-1520. Go to original source... Go to PubMed...
    47. FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain. Dostupné z WWW: <http://www.fda.gov/Drugs/DrugSafety/ucm459579.htm>.
    48. Bussey MR, Emanuele MA, Lomasney LM et al. Sitagliptin-induced bilateral Achilles tendinitis. Rheumatology 2013; 53(4): 630. Dostupné z DOI: <http://dx.doi.org/10.1093/rheumatology/ket395>. Go to original source... Go to PubMed...
    49. Cresswell FV, Tomlins J, Churchill DR et al. Achilles tendinopathy following Kaletra (lopinavir/ritonavir) use. Int J STD AIDS 2014; 25(11): 833-835. Dostupné z DOI: <http://dx.doi.org/10.1177/0956462414523403>. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.