Může být "non-alcoholic fatty liver disease" nezávislým per se rizikovým faktorem mimojaterních onemocnění? - editorial

Jiří Ehrmann, Vlastimil Procházka

Vnitr Lek 2017, 63(12):926-928 | DOI: 10.36290/vnl.2017.166  

Léčba selenem u tyreopatií - editorial

Zdeněk Fryšák

Vnitr Lek 2017, 63(12):929 | DOI: 10.36290/vnl.2017.167  

Postavení warfarinu v dnešní době: budeme jej ještě potřebovat? - editorial

Jan Kvasnička

Vnitr Lek 2017, 63(12):930-931 | DOI: 10.36290/vnl.2017.168  

Tendinopatie - editorial

Ladislav Šenolt

Vnitr Lek 2017, 63(12):932-933 | DOI: 10.36290/vnl.2017.169  

Stillova choroba dospělých - editorial

Martina Skácelová

Vnitr Lek 2017, 63(12):934  

How to apply the ambulatory cardiovascular rehabilitation: guidelines of the Working group for cardiovascular rehabilitation at Slovak Society of Cardiology

Štefan Farský, Viliam Rus, Katarína Sládeková

Vnitr Lek 2017, 63(12):972-979 | DOI: 10.36290/vnl.2017.177  

Authors have proposed a concept of guidelines for applying the ambulatory complex cardiovascular rehabilitation (ACCVR) into the clinical practice in Slovakia. As a background they have used an actual cardiovascular mortality and morbidity data from home country and abroad as well. They emphasize the non-optimal situation in this aspect which may not be solved by the increasing supporting the invasive revascularization methods and by the intensifying pharmacotherapy only, because the favourable effects of these procedures is timely missing if it is not accompanied by the therapeutic lifestyle changes. In this proposal the ACCVR is considered not as...

Diagnostic and prognostic biomarkers in acute coronary syndrome

Petr Kubena, Jindřich Špinar, Milan Dastych, Petr Lokaj, Jiří Pařenica

Vnitr Lek 2017, 63(12):935-944 | DOI: 10.36290/vnl.2017.171  

Acute myocardial infarction (AMI) is an important cause of mortality and morbidity worldwide. Early diagnostics of this disease helps in the appropriate treatment of patients. Great attention is paid to the diagnostic and risk stratification of patients according to circulating biomarkers. There are a lot of scientific publications describing this topic. The aim of this article is to provide a comprehensive overview of the most important and most examined biomarkers in acute coronary syndrome. Meanwhile troponin takes a fundamental place for AMI diagnostic (mostly the high-sensitive methods) in preference to MB-fraction of creatine kinase and myoglobin....

Adiponectin in patients with metabolic syndrome and diseases of the liver, bile ducts and pancreas

Adam Vašura, Martin Blaho, Petr Dítě, Tomáš Kupka, Pavel Svoboda, Arnošt Martínek

Vnitr Lek 2017, 63(12):945-948 | DOI: 10.36290/vnl.2017.172  

Epidemiological data show that the metabolic syndrome can be diagnosed in up to 30 % of the population. Regarding 5 components of the metabolic syndrome, three of them, in case of positivity (visceral obesity, arterial hypertension, hypertriglyceridemia, changes of HDL-cholesterol levels and type 2 diabetes mellitus), are pathogenic factors which are the most frequently related to cardiovascular diseases, but currently they are also the focus of interest for gastroenterologists. The relationship between non-alcoholic hepatic steatosis, including non-alcoholic steatohepatitis, has been described. Less is known so far about the relation to the pancreas...

Selenium treatment in thyreopathies

Štefan Sotak

Vnitr Lek 2017, 63(12):949-951 | DOI: 10.36290/vnl.2017.173  

Selenium (latin Selenium) is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet and geographic area. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. The literature suggests that selenium supplementation of patients with Hashimoto's thyroiditis is associated with a reduction in antithyroperoxidase antibody levels. Selenium supplementation also in mild Graves' orbitopathy is associated with delayed progression of ocular...

Citalopram and QT prolongation

Štefan Alušík, Zoltán Paluch

Vnitr Lek 2017, 63(12):952-956 | DOI: 10.36290/vnl.2017.174  

In 2011/2012, the US Food and Drug Administration issued a warning about the effect of citalopram on the QT interval and decreased its dosing. Further studies addressing this issue have been published since then. The authors were interested to know whether or not the studies have furnished new information that could modify or further specify the FDA-issued recommendations. After analyzing the most relevant studies, the authors concluded that even papers published within the last 5 years confirmed that, of the SSRI class of drugs, citalopram prolongs the QT interval most significantly. While the QT interval prolongation in young and otherwise healthy...

The current role of warfarin

Jana Michalcová, Alena Buliková, Jiřina Zavřelová, Marie Prudková, Miroslav Penka

Vnitr Lek 2017, 63(12):957-966 | DOI: 10.36290/vnl.2017.175  

Well-managed warfarin therapy remains an important method of anticoagulation in the 21^st century, despite the introduction of new antithrombotics into the clinical practice. The main advantages of warfarin are decades of treatment experience, the possibility to monitor its anticoagulant effect using the INR and the last, but not least, the low cost. Currently, approximately 75 % of anticoagulated patients in the Czech Republic are treated with warfarin and warfarin remains the only option for oral anticoagulant therapy in certain clinical conditions (particularly in patients with valvular atrial fibrillation or mechanical heart valves)....

Drug induced tendon injury

Štefan Alušík, Zoltán Paluch

Vnitr Lek 2017, 63(12):967-971 | DOI: 10.36290/vnl.2017.176  

Tendon injury belongs to the less known side effects of some drugs, reported until recently only for glucocorticoids and fluoroquinolones. To date, some other classes of drugs such as statins, aromatase inhibitors, anabolic steroids, potentially causing tendon injury, have been added to the list. The authors discuss the most common clinical presentations, diagnosis, and management as well as latest experimental data regarding this issue. The most often, the Achilles tendon is affected, however, nearly every tendon of the entire body may be affected. Tendon rupture or drug induced tendinopathy should be strongly considered in those who have a tendon...

Unusual history of Wilson disease: a case report and review of the literature

František Nehaj, Marianna Kubašková, Michal Mokáň, Juraj Sokol, Vladimír Nosáľ, Kamil Zeleňák, Marián Mokáň

Vnitr Lek 2017, 63(12):980-986 | DOI: 10.36290/vnl.2017.178  

Wilson disease (WD) belongs to autosomal recessive genetic metabolic disorders with gene mutation ATP7B located on 13^th chromosome. The enzyme ATPase plays an important role in WD. It facilitates excretion of copper into bile. This gene is responsible for modification of apoceruloplasmin. In this disease, it leads to insufficient release of copper from organism and accumulation of copper in organs such as liver, brain which can cause dysfunction of a certain organ. According to specific symptoms, we can divide WD into psychiatric, neurologic or hepatic form. The WD usually manifests between 15 and 25 years of age. Hepatic form often...

Remission of steroid-resistant Still's disease treated with anakinra, evidenced by FDG-PET/CT examination: case report

Zdeněk Adam, Jana Skřičková, Milan Krtička, Zdeněk Řehák, Renata Koukalová, Andrea Šprláková, Marta Krejčí, Luděk Pour, Zdenka Adamová, Eva Pourová, Zdeněk Král

Vnitr Lek 2017, 63(12):987-997 | DOI: 10.36290/vnl.2017.179  

After elimination of infectious causes, neoplastic causes and the systemic autoimmune disease of connective tissue, a patient with high fevers over 39 °C was diagnosed with Still's disease. High doses of prednisone led to resolution of symptoms, however after reducing the doses of prednisone to 15 mg, high fevers over 39 °C returned, as well as joint pains. The high doses of prednisone led to decompensation of diabetes mellitus even with 4 daily insulin dosages. Therefore it was proceeded to regular subcutaneous administration of anakinra once a day. Anakinra enabled the reduction of prednisone to as much as the currently administered 2.5 mg a day,...

Václav Procházka, Petr Novobilský et al. Atlas vaskulární diagnostiky a intervenčních výkonů

Miroslav Bulvas

Vnitr Lek 2017, 63(12):1001  

Eva Kočová, Martina Vašáková. HRCT u intersticiálních procesů v instruktivních kazuistikách

Pavel Eliáš

Vnitr Lek 2017, 63(12):1001-1002  

Jan Bruthans. Kardiovaskulární onemocnění v České republice v letech 1965-2014 a faktory, které je ovlivňovaly

Miroslav Souček

Vnitr Lek 2017, 63(12):1002  

Lukáš Zlatohlávek et al. Interna pro bakalářské a magisterské

Jaroslav Rybka

Vnitr Lek 2017, 63(12):1003  

Zemřel prof. MUDr. Karel Trnavský, DrSc.

Štefan Alušík

Vnitr Lek 2017, 63(12):998-999  

EASD Postgraduate Course of Clinical Diabetes and its Complications

Jan Brož

Vnitr Lek 2017, 63(12):1000