Vnitr Lek 2021, 67(2):114-118 | DOI: 10.36290/vnl.2021.024

Massive pulmonary embolism with a large thrombus stuck in patent foramen ovale - an impending paradoxical embolism

Josef Hornof, Ondřej Čermák
Interní oddělení, Nemocnice Slaný, Slaný

Patent foramen ovale is a persisting communication between the left and right atrium, present in approximately 25% of population, usually asymptomatic. Under normal conditions there is either no blood flow or a hemodynamically nonsignificant left-to-right shunt between the atria. However, increased right atrium pressure, as it is in pulmonary embolism, can make PFO a right-to-left shunt and poses a risk of paradoxical systemic embolism, including the risk of ischemic stroke. Here we report a case of a patient presenting with venous thromboembolism provoked by a recent polytrauma. We identified a large thrombus stuck in patent foramen ovale - an impending paradoxical embolism. Both surgical intervention and systemic thrombolysis were contraindicated so the patient was administered an anticoagulation treatment with unfractionated heparin and warfarin. By frequent echocardiography we were able to monitor complete resolution of the thrombus by 6 months from the diagnosis, with no systemic embolism.

Keywords: anticoagulation, impending paradoxical embolism, patent foramen ovale, pulmonary embolism.

Published: April 21, 2021  Show citation

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Hornof J, Čermák O. Massive pulmonary embolism with a large thrombus stuck in patent foramen ovale - an impending paradoxical embolism. Vnitr Lek. 2021;67(2):114-118. doi: 10.36290/vnl.2021.024.
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References

  1. Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects. Circ Res 2016; 118(9): 1340-1347. Dostupné z DOI: . Go to original source... Go to PubMed...
  2. Anderson FA, Spencer FA. Risk factors for venous thromboembolism. Circulation 2003; 107(23 Suppl 1): 19-116. Dostupné z DOI: . Go to original source... Go to PubMed...
  3. Pristipino C, Sievert H, D'Ascenzo F et al. European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism. Eur Heart J 2019; 40(38): 3182-3195. Dostupné z DOI: . Go to original source... Go to PubMed...
  4. Windecker S, Stortecky S, Meier B. Paradoxical Embolism. J Am Coll Cardiol 2014; 64(4): 403-415. Dostupné z DOI: . Go to original source... Go to PubMed...
  5. Homma S, Sacco RL, Di Tullio MR et al. Effect of medical treatment in stroke patients with patent foramen ovale: patent foramen ovale in Cryptogenic Stroke Study. Circulation 2002; 105(22): 2625-2631. Dostupné z DOI: . Go to original source... Go to PubMed...
  6. Takagi H, Umemoto T. et al. A meta‑analysis of case‑control studies of the association of migraine and patent foramen ovale. J Cardiol 2016; 67(6): 493-503. Dostupné z DOI: . Go to original source... Go to PubMed...
  7. Bonvini RF, Robert‑Ebadi H, Fontana P et al. Impending paradoxical embolism: When and how to treat. Annales de Cardiologie et d'Angéiologie 2008; 57(4): 234-237. Dostupné z DOI: . Go to original source... Go to PubMed...
  8. Meacham RR, Headley AS, Bronze MS et al. Impending Paradoxical Embolism. Arch Intern Med 1998; 158(5): 438-448. Dostupné z DOI: . Go to original source... Go to PubMed...
  9. Nellessen U, Daniel WG, Matheis G et al. Impending paradoxical embolism from atrial thrombus: correct diagnosis by transesophageal echocardiography and prevention by surgery. J Am Coll Cardiol 1985; 5(4): 1002-1004. Dostupné z DOI: . Go to original source... Go to PubMed...
  10. Erkut B, Kocak H, Becit N et al. Massive Pulmonary Embolism Complicated by a Patent Foramen Ovale with Straddling Thrombus: Report of a Case. Surg Today 2006;36(6):528-33. Dostupné z DOI: . Go to original source... Go to PubMed...
  11. Mirijello A et al. Paradoxical embolism with thrombus stuck in a patent foramen ovale: a review of treatment strategies. Eur Rev Med Pharmacol Sci 2018;22(24):8885-8890. Dostupné z DOI: . Go to PubMed...
  12. Myers PO, Bounameaux H, Panos A et al. Impending paradoxical embolism: systematic review of prognostic factors and treatment. Chest 2010;137(1):164-170. Dostupné z DOI: . Go to original source... Go to PubMed...
  13. Park CI, Noble S, Parsai C et al. High‑risk pulmonary embolism with impending paradoxical embolism successfully treated with percutaneous catheter‑based thrombectomy. Cardiovasc Med 2011;14:127-30. Dostupné z DOI: Go to original source...
  14. Ishida T et al. A Successful Treatment Strategy for Paradoxical Cerebral Embolism Accompanied by Entrapped Thrombus in Patent Foramen Ovale. Intern Med 2020;59(2):211-214. Dostupné z DOI: . Go to original source... Go to PubMed...
  15. Varvařovský I, Mates M, Horák D et al. Odborné stanovisko pro uzávěr otevřeného foramen ovale (PFO) Společný dokument České asociace intervenční kardiologie České kardiologické společnosti, České neurologické společnosti a České asociace kardiovaskulárních zobrazovacích metod České kardiologické společnosti. Interv Akut Kardiol 2020; 19(1): 18-23. Dostupné z DOI: . Go to original source...




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