Vnitr Lek 2023, 69(7):466-468 | DOI: 10.36290/vnl.2023.090

Can measurements of arterial stiffness detect patients with hypertension at increased dementia risk?

Jitka Mlíková Seidlerová
II. interní klinika FN a LF v Plzni

Recent data suggest that we are on the verge of a dementia pandemic. Hypertension is a significant risk factor for this so far untreatable irreversible condition. The attention of researchers is now focused on identifying individuals at increased risk of cognitive decline or with early-stage cognitive deficit. Apart from cognitive function tests and imaging studies, no suitable biomarkers to identify these individuals have been available as yet. Haemodynamic parameters could be potentially useful biomarkers. At the ESH 2022 Congress, Professor Cunha presented the current knowledge suggesting that cognitive decline could be related to visit-to-visit blood pressure variability, carotid artery intima media thickness, and aortic stiffness as measured by pulse wave velocity (PWV). Currently, the CEREBRO study is being conducted to evaluate the prevalence of cognitive dysfunction in patients with hypertension and to search for early vascular biomarkers that correlate with cognitive decline. In addition to early and tight control of blood pressure, early detection of cognitive impairment could be a way to reduce the prevalence of advanced stages of dementia in the future.

Keywords: dementia, cognitive deficit, hypertension, arterial stiffness, pulse wave velocity, cerebral small vessel disease, CEREBRO study.

Accepted: October 19, 2023; Published: October 26, 2023  Show citation

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Mlíková Seidlerová J. Can measurements of arterial stiffness detect patients with hypertension at increased dementia risk? Vnitr Lek. 2023;69(7):466-468. doi: 10.36290/vnl.2023.090.
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    References

    1. Cunha PG. The CEREBRO study (CEntRal hEmodynamics, Blood pRessure and cognitiOn). Prezentováno na kongresu EHS, Atény, Cited 17. 6. 2022
    2. Rouch L, Cestac P, Sallerin B, et al. S.AGES investigators. Visit­‑to­‑Visit Blood Pressure Variability Is Associated With Cognitive Decline and Incident Dementia: The S.AGES Cohort. Hypertension. 2020 Oct;76(4):1280-1288. Go to original source... Go to PubMed...
    3. Guimarães Cunha P, Stolarz­‑Skrzypek K, Persu A. Increased Blood Pressure Variability May Herald Cognitive Decline and Dementia. Hypertension. 2020 Oct;76(4):1076-1078. Go to original source... Go to PubMed...
    4. Iulita MF, Noriega de la Colina A, Girouard H. Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk? J Neurochem. 2018 Mar;144(5):527-548. Go to original source... Go to PubMed...
    5. van Sloten TT, Sedaghat S, Laurent S, et al. Carotid stiffness is associated with incident stroke: a systematic review and individual participant data meta­‑analysis. J Am Coll Cardiol. 2015 Nov 10;66(19):2116-2125. Go to original source... Go to PubMed...
    6. Zeki Al Hazzouri A, Vittinghoff E, Sidney S, et al. Intima­‑Media Thickness and Cognitive Function in Stroke­‑Free Middle­‑Aged Adults: Findings From the Coronary Artery Risk Development in Young Adults Study. Stroke. 2015 Aug;46(8):2190-2196. Go to original source... Go to PubMed...
    7. Ben­‑Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta­‑analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014 Feb; 63(7): 636-646. Go to original source... Go to PubMed...
    8. Mitchell GF, van Buchem MA, Sigurdsson S, et al. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study. Brain. 2011 Nov;134(Pt 11):3398-3407. Go to original source... Go to PubMed...
    9. Pase MP, Himali JJ, Mitchell GF, et al. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle­‑Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. 2016 Mar. 67(3): 513-519. Go to original source... Go to PubMed...
    10. Pase MP, Beiser A, Himali JJ, et al. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia. Stroke. 2016 Sep;47(9):2256-2261. Go to original source... Go to PubMed...
    11. Jefferson AL, Cambronero FE, Liu D, et al. Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults. Circulation. 2018 Oct 30;138(18):1951-1962. Go to original source... Go to PubMed...
    12. van Sloten TT, Protogerou AD, Henry RM, et al. Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta­‑analysis. Neurosci Biobehav Rev. 2015 Jun;53:121-130. Go to original source... Go to PubMed...
    13. Hajjar I, Goldstein FC, Martin GS, Quyyumi AA. Roles of Arterial Stiffness and Blood Pressure in Hypertension­‑Associated Cognitive Decline in Healthy Adults. Hypertension. 2016 Jan;67(1):171-175. Go to original source... Go to PubMed...
    14. Alvarez­‑Bueno C, Cunha PG, Martinez­‑Vizcaino V, et al. Arterial Stiffness and Cognition Among Adults: A Systematic Review and Meta­‑Analysis of Observational and Longitudinal Studies. J Am Heart Assoc. 2020 Mar 3;9(5):e014621. Go to original source... Go to PubMed...
    15. Wohlfahrt P. Porucha kognitivních funkcí a hrozba pandemie demence aneb cesta hypertoniků k nesoběstačnosti, Vnitř Lék. 2022;68(8):532-536 Go to original source... Go to PubMed...

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