Péče o trvalé vstupy pacientů na domácí parenterální výživě - editorial

M. Šenkyřík, J. Juránková

Vnitr Lek 2012, 58(12):892-893  

Pozor na "přírodní" léčbu - játra mohou trpět! - editorial

P. Husa

Vnitr Lek 2012, 58(12):894-895  

Outcomes of AL-amyloidosis treatment with bortezomib, dexamethasone and cyclophosphamide or doxorubicin-containing regimens

Z. Adam, M. Štork, L. Pour, M. Krejčí, L. Zahradová, V. Sandecká, R. Hájek, Z. Čermáková, Y. Pospíšilová, M. Navrátil, Z. Král, J. Mayer

Vnitr Lek 2012, 58(12):896-903  

According to the criteria for multiple myeloma, systemic AL-amyloidosis may be divided into primary systemic AL-amyloidosis, where monoclonal gametopathy is present but the criteria for multiple myeloma are not satisfied, and systemic AL-amyloidosis with underlying multiple myeloma. There is a continuous transition between the two units. The present paper describes treatment of patients with established systemic AL-amyloidosis who satisfy the 2003 International Myeloma Working Group's criteria for symptomatic multiple myeloma (confirmed monoclonal immunoglobulin, clonal plasmocytes confirmed in the bone marrow and at least one clinical symptom of myeloma...

Is antiplatelet therapy always effective?

A. Remková, A. Janušicová, M. Remko

Vnitr Lek 2012, 58(12):904-914  

Objective:Acetylsalicylic acid (ASA) and clopidogrel (KLP) therapy is associated with the high degree of variability in response to the drug and some patients are drug-resistant. The aim of our study was to evaluate the individual response to antiplatelet therapy in patients at high risk of cardiovascular events treated with ASA (n = 131), KLP (n = 51) or ASA + KLP (n = 34). Subjects and methods:Investigations were performed in them by light transmission aggregometry and in selected patients by VASP fosforylation. Results:Good response to ASA treatment with arachidonic acid-induced platelet aggregation inhibition...

Our experience with the treatment of primary lymphomas of the central nervous system

M. Motyčková, L. Smolej, D. Belada, J. Malý, P. Žák

Vnitr Lek 2012, 58(12):915-921  

Introduction:The aim of this study was to assess treatment efficiency, overall survival (OS) and identify risk factors with the influence on patients prognosis in patients with primary central nervous system lymphomas (PCNSL) who were treated with intensive chemotherapy based on high-dose methotrexate and cytosin-arabinoside followed by whole-brain radiotherapy (MPV regimen). Patients and methods:From January 1998 to February 2011, 39 patients with PCNSL were diagnosed on our department. The median from the first clinical symptomatology to histological diagnosis was 4 weeks (range, 2-19). Thirty-seven patients were treated...

Arterial hypertension in gravidity - a risk factor for cardiovascular diseases

M. Kováčová, S. Kiňová

Vnitr Lek 2012, 58(12):922-927  

Gravidity is a dynamic process and complications may occur at any stage and anytime during a thus far physiological gravidity. Such gravidity puts the mother, the foetus and, later, the newborn at a greater risk. The incidence of arterial hypertention is between 7 and 15% and is one of the 4 main causes of maternal and perinatal mortality. Cardiovascular stress test, such as gravidity, might help to identify women at a greater risk of cardiovascular diseases or with a subclinical vascular disease. Women with a history of preeclampsia are more likely to develop chronic arterial hypertension in the future either alone or associated with a cardiovascular...

Current opinions on gout, its diagnosis and treatment

P. Němec

Vnitr Lek 2012, 58(12):928-937  

Gout is a heterogenous group of metabolic diseases characterized by formation and deposition of sodium urate crystals in various tissues. Gouty arthritis is a rheumatic syndrome occurring in individuals with hyperuricaemia; this is an inflammatory disease of the musculoskeletal system with a presence of sodium urate crystals. Hyperuricaemia, i.e. pathologically increased levels of uric acid in the serum, represents the most important risk factor for the development of gouty arthritis. The causes of hyperuricaemia may include an increased production of uric acid and/or its reduced elimination from the body. Acute gouty arthritis is an early manifestation...

Primary cilia of cells of cardiovascular apparatus

J. Dvořák, V. Sitorová, D. H. Nikolov, J. Mokrý, I. Richter, S. Filip, A. Ryška, J. Petera

Vnitr Lek 2012, 58(12):938-942  

The primary cilium is a mechanosensory, solitary, non-motile microtubule-based structure that in the quiescent phase of the cell cycle projects from the surface of the majority of human cells, including embryonal, stem and mesenchymal cells, fibroblasts, myoblasts, cardiomyocytes, vascular smooth muscle and endothelial cells. Primary cilia are in increased frequency also present on the surface of endothelial cells in atherosclerotic predilection sites, lipoid streaks and dots and atheromatous plaques. The primary cilium is formed from the mother centriole. Primary cilia are currently studied in mechanobiology of cardiovascular apparatus and their role...

Population-level changes to promote cardiovascular health

T. Jørgensen, S. Capewell, E. Prescott, S. Allender, S. Sans, T. Zdrojewski, D. De Bacquer, J. de Sutter, O. H. Franco, S. Løgstrup, M. Volpe, S. Malyutina, W. M. M. Verschuren, D. Vanuzzo

Vnitr Lek 2012, 58(12):943-954  

Background:Cardiovascular diseases (CVD) cause 1.8 million premature (

Current guidelines on the care of tunelized vascular catheters in patients on home parenteral nutrition

J. Víšek, J. Maňák, R. Šafránek, M. Kubišová, R. Dlouhá, L. Sobotka, V. Bláha

Vnitr Lek 2012, 58(12):955-957  

Home parenteral nutrition is the only option to provide nutrition in a number of patients. Care of venous entry, its management and treatment of complications resulting from its use importantly affect patient survival. Appropriate care of the catheter and the use of current knowledge may prolong the lifespan of the catheter, reduce patient morbidity and mortality and thus increase quality of life of patients who are dependent on home parenteral nutrition. The present paper summarizes recommendations for the care of long-term venous catheters.

Toxic hepatitis induced by Polygonum multiflorum

A. Baňárová, T. Koller, J. Payer

Vnitr Lek 2012, 58(12):958-962  

Toxic liver injury is a common cause of acute hepatitis. Here we report a case of 33-year old female with toxic hepatitis caused by unusual agent - extract of chinese plant Polygonum multiflorum. The patient presented with clinical signs of nausea and icterus and laboratory signs of hepatocellular damage following 2 months of readministration of Polygonum mulltiflorum pills. All other causes of hepatocellular damage were excluded. The causality between hepatocellular damage and Polygonum multiflorum ingestion was supported by early recovery after discontinuation, by international scoring system of causality between drug and hepatotoxicity as well as...

Používání koncentrátu protrombinového komplexu brzdí terapeutický nihilismus

Vnitr Lek 2012, 58(12):963-965  

Oznámení o konání XXXII. Dnů mladých internistů

Josef Zadražil

Vnitr Lek 2012, 58(12):966  

Seznam členů výboru Slovenskej internistickej spoločnosti na roky 2011-2014

Vnitr Lek 2012, 58(12):966