[Relative contribution of standard and physiologic stimulation for maximal work capacity in patients with complete atrioventricular block].

J Lukl, P Heinc

Vnitr Lek 1992, 38(2):105-111

The influence of heart rate on the maximal work capacity was investigated in 18 patients (mean age 55 years) with a physiological pacemaker implanted on account of chronic complete atrioventricular block of different aetiology. Twelve patients with a dominating atrial sinus activity had a dual chamber DDD pacemaker and six patients with dominating atrial fibrillation or flutter had a single chamber QTVVIR pacemaker. The exercise test was made on a bicycle ergometer using three stimulation regimes in randomized order and without the patient's knowledge of the programmed mode of pacing: 1. VVI pacing with frequency of 30/min exercise on AV block, 2....

[Late ventricular potentials in patients without ventricular tachycardia 3 years after myocardial infarct].

P Vojtísek, J Kvasnicka, T Tusl, I Gajdosová, V Wasylivová

Vnitr Lek 1992, 38(2):112-117

In 57 patients who in the course of 29-48 months (mean 36 months) after myocardial infarction did not develop sustained ventricular tachycardia, late ventricular potentials were investigated. Positive findings were revealed in 13 (22.8%) patients using a 25-250 Hz filter and in 14 patients resp. (24.6%) using a 40-250 Hz filter. Late ventricular potentials were significantly more frequent in patients after myocardial infarction of the lower rather than the anterior wall (p less than 0.05). No differences were revealed between groups with positive and negative late ventricular potentials as regards the occurrence of repeated infarction, left-side cardiac...

[Endarterectomy of the coronary arteries].

V Fischer, I Simkovic, M Holoman, P Verchvodko, P Janotík, J Galbánek, M Hulman, J Kostelnicák, R Jurco, J Slezák

Vnitr Lek 1992, 38(2):118-121

The authors analyze 50 patients with endarterectomy of the coronary arteries during the periods of 1972-1974 and 1988-1990. The results of endarterectomy of the right and left coronary artery provide evidence of its justification in indicated cases whereby contrary to some departments the results of endarterectomy of the left coronary artery are comparable with endarterectomy of the right coronary artery.

[Comparison of the effects of diltiazem and isradipine in adrenergic beta receptor blockade in patients with stable angina pectoris].

J Meluzín, M Novák

Vnitr Lek 1992, 38(2):122-128

In 20 patients with stable angina II-III according to NYHA by means of ergometry the effect of short-term administration of dilthiazem (90 mg in three doses), placebo and isradipine (5 mg in three doses) in block of beta-receptors of the sympathetic nerve (metipranolol 3 x 10 mg/day) was compared. As compared with placebo, dilthiazem and isradipine retarded significantly the development of stenocardia, reduced the S-T depression in lead V5 and increased the total work output during ergometry. Based on the results of this and previous work (9) it may be stated that concurrent administration of metipranolol reduced the frequency of side-effects of isradipine...

[Midazolam during cardiac pacemaker implantation].

J Simícek, I Pavlů, J Chmelo

Vnitr Lek 1992, 38(2):129-131

Midazolam (Dormicum Roche) was administered to 40 patients aged 68 +/- 11 years (5 mg by the i.v. route), along with phentanyl and droperidol before primo-implantation or replacement of pacemaker under local anaesthesia. Another 5 mg were administered at the end of the operation before the final skin suture. In all patients a favourable sedative effect was achieved with rapid regression after the operation was completed, in the majority with retrograde amnesia. None of the patients developed respiratory arrest or mental alteration during the postoperative period, while in an equal number of patients in the control group both complications occurred...

[Enalapril in the treatment of nephrogenic hypertension].

J Jurecková, K Stefíková, V Spustová, R Dzúrik

Vnitr Lek 1992, 38(2):132-139

In a half-year open clinical study the authors investigated the antihypertensive action of enalapril--an inhibitor of the angiotensin converting enzyme--and its action on renal functions in a group of 11 patients with nephrogenic hypertension. In seven patients monotherapy, using a mean dose of 12 mg, was sufficiently effective. In the remaining four patients treatment was combined with diuretics. It was revealed: that: 1. a significant drop of systolic and diastolic pressure occurred with a concurrent decline of the total peripheral vascular resistance, 2. a slight (statistically not significant) reduction of the glomerular filtration as well as quantitative...

[Determination of differential renal function using 99m Tc-DMSA scintigraphy].

O Kraft, J Kuba

Vnitr Lek 1992, 38(2):140-147

By examination of 331 patients, using 99mTc-DMSA, the authors confirmed that static scintigraphy is an accurate method for assessment of the separate renal function. In four groups of patients with different positions of the kidneys the authors proved that correction for different absorption of gamma radiation from the left and right kidney is essential. Without correction results with a significant error are obtained, in particular in patients with an asymmetric position of the kidneys, where the results calculated without correction cannot be used for clinical purposes. The results are not influenced by the time interval between administration of...

[Response to a series of carbon dioxide baths].

V Strec, A Dukát, K Aksamitová, P Adolf, B Stalmaseková

Vnitr Lek 1992, 38(2):148-154

The authors investigated 28 patients, mean age 43.6 years, during their stay in spa Dudince. The patients had a daily carbon dioxide bath, thermally indifferent, for a period of 20 minutes. During the first, tenth and twentieth bath the humoral circulatory and renal response was assessed. During every bath a standard reaction developed (decline of plasma renin activity and of the aldosterone level, increased excretion of water and minerals, changes of the blood pressure and heart rate). The influence of the series of baths was manifested by a gradual increase of the diuresis, natriuresis, a more permanent drop of the blood pressure and at the end of...

[Feldene in local therapy of deforming gonarthroses].

J Vachtenheim

Vnitr Lek 1992, 38(2):155-159

The author submits the results of Feldene gel therapy which contains 5 mg piroxicam per 1 g. The preparation was applied to patients with deforming gonarthrosis, always on one joint three times per day for two weeks. The evaluation was made before the unset of treatment and on the 7th and 14th day. It was an open clinical therapeutic trial. In 97.5% the tolerance was excellent. Undesirable manifestations developed only in one female patients who had sensations of irritation which disappeared in three days and interruption of treatment was not necessary. The authors evaluated pain, mobility, required assistance during change of position-sitting and...

[Prognostication of chronic Ph+ myeloid leukemia using the PHCML.EXE computer program].

J Berger, L Chrobák, J Voglová, M Steruská

Vnitr Lek 1992, 38(2):160-165

In 193 patients with Ph-positive chronic myeloid leukaemia (CML) Sokal's calculation formulae prognosticating initial risk status were applied, using the computer program PHCML. The aim of this study was to the prognostic reproducibility of these prognostic staging systems in our patient population. Our results confirm the previous conclusions that prognostic discrimination is possible at the time of diagnosis of CML but in our patients with poorer prognosis the stratification seems to be more accurate. No significant advantage was achieved when we prognosticated our patients younger than 46 years using the formula recommended by Sokal et al. specifically...

[Comparison of Tarivid and Biseptol in the prevention of bacterial infections in patients with acute leukemia].

K Mociková, J Svác, E Faber, B Wildová, I Baníková

Vnitr Lek 1992, 38(2):166-172

In 42 patients with induction treatment of acute myeloblastic and lymphoblastic leukaemia the authors compared efficacy of selective decontamination of the gastrointestinal tract in prevention of infections during neutropenia less than 0.5.10(9)/l in two comparable groups. Twenty-two patients were treated with Ofloxacin (Tarivid, Hoechst Co.), 20 patients with Trimetroprim-Sulfamethoxazol (Biseptol, Polfa Co.). Both groups had concurrently also Ketoconazol in prevention of mycotic infection. The investigation revealed that Tarivid is a suitable alternative drug for selective decontamination, because it delays the onset of acquired infection, as compared...

[Detection of HLA-DR antigens using the ethidium bromide fluorescence test].

A Májský

Vnitr Lek 1992, 38(2):173-176

HLA-DR antigens were examined in peripheral lymphocytes by means of a one-colour fluorescent microcytotoxic test using ethidium-bromide. Evidence of HLA-DR antigens was equally reliable as the two-colour fluorescent test. Contrary to the latter, however, faint non-specific positive results were obtained in sera not containing HLA-DR antibodies. This is caused probably by the fact that ethidium-bromide penetrates into cells with a very slightly damaged membrane. This reduces substantially the possibility of introduction of the method into common practice.

[Thymoma in the anterior mediastinum and systemic lupus erythematosus].

Z Paráková, Z Hrncír, Z Nozicka

Vnitr Lek 1992, 38(2):177-183

The authors describe an observation of a thymoma and systemic lupus erythematosus (SLE) in a 48-year-old woman with an analysis of clinical and laboratory indicators justifying this diagnosis. Improvement of SLE and the lupus nephropathy was achieved by three pulses of methyl prednisolone à 1000 mg in an intravenous infusion with subsequent Prednisone therapy, using conventional doses. After thymectomy on account of a benign thymoma activation of SLE did not occur. The objective of the presented paper is to draw attention to the infrequent possible concurrent incidence of thymoma and SLE and the influence of thymectomy and the subsequent development...

[Characteristics of diabetic macroangiopathy of the lower extremities].

I Tkác, M Takác

Vnitr Lek 1992, 38(2):184-190

Macroangiopathy of the lower extremities is one of the most frequent complications of diabetes and has a very adverse impact on the quality of life of the patients. It affects approximately as much as half the diabetics with the duration of the disease for more than 15 years. It is encountered in two forms. The first type of affection--obliterating atherosclerosis--reminds of affections of the arteries of the lower extremities in the non-diabetic population, although some differences in the site of affection, morphology of sclerotic changes as well as the spectrum of risk factors were found, when compared with obliterating atherosclerosis in non-diabetics....

[Dietary recommendations of the Czech Diabetology Society for adults with diabetes mellitus].

I Rames

Vnitr Lek 1992, 38(2):204-208