Zahajovací zdravice XV. kongresu České internistické společnosti České lékařské společnosti J. E. Purkyně, Brno, 24. 9. 2008

Jaroslav Blahoš

Vnitr Lek 2008, 54(10):934  

Internistická moudrost - matka celé klinické medicíny. Metamorfózy internistova myšlení a praktického konání

V. Pacovský

Vnitr Lek 2008, 54(10):935-936  

Komentář k novým Doporučením o diagnostice a léčbě plicní embolie Evropské kardiologické společnosti (EKS) (Torbicki et al 2008) ve světle Doporučení diagnostiky, léčby a prevence plicní embolie České kardiologické společnosti - verze 2007

J. Widimský, J. Malý

Vnitr Lek 2008, 54(10):937-942  

Stanovení LDL-cholesterolu - stále nevyřešený problém: vypočíst, nebo změřit? - editorial

V. Soška

Vnitr Lek 2008, 54(10):943-944  

Nukleární kardiologie: postradatelná, či nepostradatelná? - editorial

J. Veselka

Vnitr Lek 2008, 54(10):945-947  

Srdeční amyloidóza - editorial

P. Gregor

Vnitr Lek 2008, 54(10):948-949  

Srdeční amyloidóza - podceňovaná hrozba? - editorial

J. Krejčí

Vnitr Lek 2008, 54(10):950-951  

Immediate and long-term results of conventionally performed radiofrequency catheter ablations of paroxysmal atrial fibrillation

R. Lábrová, M. Fiala, O. Toman, J. Špinar

Vnitr Lek 2008, 54(10):953-960  

Introduction:Atrial fibrillation is the most frequent cardiac arrhythmia. Epidemiological studies show sharp increase of incidence and prevalence of atrial fibrillation all over the world. Atrial fibrillation is becoming to be a serious problem, not only clinical, but even social and economical. Aim of the paper was to evaluate immediate and long-term results of radiofrequency catheter ablation of paroxysmal atrial fibrillation at Dpt. of Internal Medicine - Cardiology, University Hospital Brno. Methods:The patients were indicated for ablation, when the anti-arrhythmic therapy was ineffective. End-point of the ablation was...

Evaluation of alternative calculation methods for determining LDL cholesterol

B. Vohnout, A. Vachulová, P. Blažíček, A. Dukát, G. Fodor, J. Lietava

Vnitr Lek 2008, 54(10):961-964  

Background:Due to limitations of the Friedewald formula, alternative methods for calculating low-density lipoprotein cholesterol (LDL-C) were suggested. We evaluated utility of these methods. Methods: Ninety three subjects free of coronary heart disease were considered. LDL-C was measured by the homogeneous method, and calculated by the Friedewald formula LDL-C = TC - HDL - (TG/2.2) (LDL1) and alternative formulas LDL-C = 0.41 TC - 0.32 TG + 1.70 apoB - 0.27 (LDL2) and LDL-C = 0.94 TC - 0.94 HDL - 0.435 TG (LDL3). Results:All three formulas underestimated the measured LDL-C, both in the whole group and in subgroups...

Biomarkers of myocardial ischemia and necrosis in 2008

R. Pudil, M. Tichý, M. Ulrychová, L. Horáková, J. Vojáček

Vnitr Lek 2008, 54(10):965-970  

In the review article, the authors present current knowledge of biomarkers of myocardial ischemia and necrosis. They comment new definition of myocardial infarction resulted as consensus of European Society of Cardiology and American Heart Association. They added clinically interested data about routinely used cardiomarkers (cardiac troponins and creatinkinase). At the second part, the authors focused on new biomarkers (fatty acids binding proteins, ischemia-modified albumin, glycogen phosphorylase isoenzyme BB) and its significance in diagnosis of myocardial ischemia/necrosis and their prognostic significance. Some of new promising molecules are discussed...

Myocardial viability findings interpretation using SPECT and PET imaging

M. Kamínek, M. Hutyra

Vnitr Lek 2008, 54(10):971-978  

Myocardial perfusion and function imaging using single photon emission computed tomography (SPECT) plays the important role in coronary artery disease diagnostics and risk stratification, however, there is nowadays growing significance of the myocardial viability detection. A glucose metabolism assessment using positron emission tomography (PET) becomes accessible also. A brief review is given about the interpretation principle in the viable myocardium diagnosis and current progress in perfusion and metabolism defect severity quantification in patients with the left ventricular dysfunction.

Colorectal carcinoma and diabetes mellitus

V. Procházka, R. Chlup

Vnitr Lek 2008, 54(10):979-984  

The aim of this overview notification is to point out the risk factors and causes of colorectal carcinoma in diabetics. On the basis of recent information in the literature Type 2 diabetes mellitus has begun to appear as a potential risk factor for colorectal carcinoma. The work focuses on the link between them and outlines a possible solution to this topical issue. When tracking the diabetic population it is recommended that current depistage programmes for colorectal carcinoma be strictly maintained, that dispensing programmes not be neglected, in working with gastroenterologists to share the planning and specific preparation of a diabetic for endoscopy...

Dual antiplatelet treatment

J. Krupička

Vnitr Lek 2008, 54(10):985-991  

Atherothrombosis is the most frequent cause of cerebrovascular and cardiovascular incidents. In spite of indisputable progress in treatment the residual risk remains high. Further means are needed to improve the prognosis for patients. Just as in the treatment of hypertension or dyslipidemia we are presently going down the route of combined medication, which affects the thrombosis process at different stages and thus increases the final effect. The article summaries the current possibilities for dual antiplatelet treatment and its indications.

Hemophilia

P. Smejkal, M. Matýšková, M. Penka

Vnitr Lek 2008, 54(10):992-999  

Hemophilia is the most spread hereditary bleeding disorder with severe bleeding symptoms. Although the number of hemophiliacs is below 0.1‰ in population, the care of these patients consumes a lot of financial expenditures, especially for treatment in appearance of inhibitor. Management of hemophilia is best provided by specialist in a hemophilia treatment centre. However, all physicians can meet the patients with hemophilia in urgent situation or with their chronic problems. The aim of this article is to give an overview of this disease from pathophysiology, clinical manifestation and diagnosis (including prenatal) to treatment. We describe...

Hemopurification in sepsis: current view

R. Sýkora, J. Chvojka, A. Kroužecký, J. Raděj, T. Karvunidis, I. Novák, M. Matějovič

Vnitr Lek 2008, 54(10):1000-1005  

Sepsis is the leading cause of mortality in non-coronary intensive care units. The uncontrolled and deregulated systemic inflammatory response to infection plays a central role in the pathophysiology of sepsis. This response is mediated by a broad spectrum of endogenous mediators leading to dysfunction in multiple organs remote from the primary infectious site. The failure of numerous clinical trials aimed at eliminating a single mediator stimulated the research to focus on non-selective removal of excessively produced mediators of sepsis. This "detoxification" forms the theoretical basis and biological rationale for the use of hemopurification therapies...

Cardiac Arrhythmias in Obstructive Sleep Apnea

P. Schweitzer

Vnitr Lek 2008, 54(10):1006-1009  

Obstructive sleep apnea syndrome (OSA) is associated with different types of cardiac arrhythmias. The original studies, concentrated mostly on nocturnal brady- and tachyarrhythmias. More recent studies documented high prevalence of atrial fibrillation (AF) and its association with obesity and other risk factors for AF. In addition, continuous positive airway pressure (CPAP) prevents recurrence of AF after cardioversion. In, OSA the highest risk for sudden death is at night in comparison to general population most of who die suddenly between six and noon. This observation suggests that hypoxia or other nocturnal abnormality, trigger sudden death. An...

The isolated form of cardiac amyloidosis in the form of beginning infiltrative cardiomyopathy without restrictive physiology

P. Kuchynka, T. Paleček, S. Šimek, J. C. Lubanda, M. Elleder, I. Špička, P. Jansa, A. Linhart

Vnitr Lek 2008, 54(10):1010-1013  

The authors describe an interesting case of isolated cardiac manifestation of AL-amyloidosis manifesting as an incipient infiltrative cardiomyopathy with heart failure symptoms due to moderate left ventricular diastolic dysfunction. Restrictive cardiomyopathy with severe diastolic dysfunction is considered as the characteristic manifestation of fully developed cardiac amyloidosis. However, the organ deposition of amyloid is progressive and left ventricular filling worsens continuously, starting with less advanced forms of diastolic dysfunction; the restrictive physiology is characteristic only for advanced phases of the disease. Therefore, the possibility...

Myopathy and mixed hyperlipoproteinemia as the first symptom of systemic AL-amyloidosis

M. Tošovský, T. Soukup, P. Bradna, V. Maisnar, V. Tyčová, J. Tomš, M. Prixová

Vnitr Lek 2008, 54(10):1014-1019  

Systemic AL-amyloidosis is a disorder brought about by the over-production and deposition of fragments of light immunoglobulin chains in tissues, the consequence of which is their functional impairment. The most often affected are the kidneys, the heart, the gastro-intestinal tract and the nervous system. We describe the case of a 57-year old patient in whom a rare disorder of the striated muscle (am yloid myopathy) was present, as the first clinical indication of systemic AL-amyloidosis. The main symptoms were muscle weakness and an increase in laboratory signs of muscle lesion. The patient was monitored for several years and treated with a diagnosis...

Viklický O, Janoušek I, Baláž P et al. Transplantace ledviny v klinické praxi

Otto Schück

Vnitr Lek 2008, 54(10):1022  

XIV. medzinárodný kongres pre výživu a metabolizmus pri chorobách obličiek, 11.-15. júna 2008, Marseille (Francúzsko)

M. Mydlík, K. Derzsiová

Vnitr Lek 2008, 54(10):1020-1021