Vnitr Lek 1989, 35(1):43-49

[Relation of HLA antigens and the length of survival in patients with acute leukemia].

J Prazák

The authors examined and evaluated by statistical methods 80 patients with acute leukaemia (AL). The group comprised 56 myeloid (AML) and 24 lymphocytic (ALL) leukaemias. In AL and AML no significant relations with transplantation antigens were detected. In ALL an increased frequency of HLA-B5 was found which was statistically significant (Fischer's test pc = 0.046). In women, as compared with men, an increased frequency of antigens A28, B17 was found and a reduction of HLA-B35. The values were not statistically significant. The authors sought relationships between the presence or absence of some HLA antigens (A2, A3, A10, B12) and the survival period of the patients. The results were not unequivocal. The findings were evaluated with regard to data reported in the literature.