Vnitr Lek 1989, 35(7):645-649

[HLA antigens and primary prolapse of the mitral valve].

I Rybár, V Bosák, V Rus, M Ondrasík

Klíčová slova: Adolescent; Adult; Female; HLA Antigens, analysis, ; HLA-B35 Antigen, analysis, ; Humans; Male; Middle Aged; Mitral Valve Prolapse, immunology,

The authors present results of investigation of antigens of the HLA system in primary mitral valvular prolapse. The investigated group of patients was formed by 23 not related patients with primary mitral valvular prolapse. (15 women, 8 men, aged 18-55 years) where HLA antigens of loci A, B and C were assessed. They found a significantly increased frequency of antigen HLA-B35 in the patients (56.52%), as compared with the population (18.33%, x2 = 18.48, Pcorr less than 0.01). The measure of the observed relationship is expressed by the relative risk value--RR = 5.81. The difference in the frequency of the other HLA antigens was not statistically significant.