Vnitr Lek 1992, 38(10):963-967
[Combined therapy with insulin/gliquidone (Glurenorm) in type 2 diabetes after treatment failure using oral antidiabetic agents].
- II. interní klinika lékarské fakulty MU, Brno.
Klíčová slova: Adult; Aged; Blood Glucose, analysis, ; Diabetes Mellitus, Type 2, blood, ; Female; Humans; Hypoglycemic Agents, therapeutic use, ; Male; Middle Aged; Sulfonylurea Compounds, therapeutic use,
The authors evaluate treatment by a combination of insulin and gliquidone (Glurenorm) in 29 type 2 diabetics where long-term treatment with oral antidiabetics alone had failed. Within four months all patients were completely compensated from the metabolic aspect. HbA1c declined from 10.8 to 6.5, C peptide, on the other hand, increased from the original value of 1.2 ng/ml to 1.8 ng/ml. The authors did not observe any undesirable effects or hypoglycaemic states. Gliquidone is suitable for combined treatment because of its short-term effect; stimulation of endogenous secretion has a pulsed character and imitates an intensified regime. The prerequisite of success is a low dose of intermediary insulin to prevent inhibition of the central action of gliquidone.
Keywords: Adult; Aged; Blood Glucose /analysis/; Diabetes Mellitus, Type 2 /blood/; Female; Humans; Hypoglycemic Agents /therapeutic use/; Male; Middle Aged; Sulfonylurea Compounds /therapeutic use/
Zveřejněno: 1. říjen 1992 Zobrazit citaci