Vnitr Lek 1993, 39(10):1013-1021

[Damage caused by monoclonal immunoglobulins and possibilities of therapy. 2].

Z Adam: II. interní klinika Fakultní nemocnice, Brno, Bohunice.

Klíčová slova: Humans; Immunoglobulins, metabolism, ; Paraproteinemias, immunology,

Monoclonal immunoglobulins (M-Ig) cause due to their chemical structure and physical properties some pathological manifestations. In the text all skin changes are analyzed which are supposed to be associated with M-Ig. Some light chains form amyloid masses which can damage almost all organs. M-Ig can perhaps enhance also the capillary permeability although their role in the capillary leak syndrome remains obscure.