Vnitr Lek 1998, 44(11):671-674

[A new model of hemostasis].

P Galajda, D Baláz, M Mokán, P Kubisz: I. interná klinika, Jesséniova lekárska fakulta, Martin.

Klíčová slova: Hemostasis, physiology, ; Humans; Models, Cardiovascular; Thrombosis, physiopathology,

Haemostasis is a complexly controlled process which takes place in two stages. The first initial stage leads to the formation of a small amount of thrombin. The crucial step of initiation is the bond between the activated factor VIIa and the tissue factor. It is regulated by interaction between factors promoting and inhibiting the process of thrombogenesis. The initiation of haemostasis must be associated with the formation of the thrombus and for effective fibrinogenesis the second stage, amplification of haemostasis, is necessary. A new two-stage model of coagulation imitates the process of haemostasis in vivo as the classical MacFarlan cascade model and makes it possible to explain the pathogenesis of prothrombotic conditions.