During five years (1992-1997) 215 patients with solitary brain metastases were treated in the Department of Stereotactic and Radiation Neurosurgery (117 men and 98 women). The most frequent first neurological symptoms were: headache, hemiparesis, seizure, mental and behavioural disturbances. Location of lesion was supratentorial in 163 patients (75.8%) and infratentorial in 52 cases (24.2%). Treatment results: complete and partial regression in 175 patients (81.4%), stabilisation in 30 of patients (14.0%), local progression in 10 patients (4.6%). Local recurrence after initially effective treatment was observed in 11 pts (5.1%). The severity of neurological symptoms was measured by RTOG 4 grades scoring system. The acute and late toxicity was evaluated by SOMA scale (RTOG--Radiation Therapy Oncology Group): grading 0-5. We observed acute toxicity (score 3 and 4) in 20 patients (9.3%) and late (score 3 and 4) in 9 patients (4.2%). Minimal follow up for all patients was 10 months. Median survival for 159 dead patients was 7 months (ranged from 2 to 35 months), median survival for surviving 56 pts was 15.5 months (ranged from 10 to 56 months). One-year survival was 39.5% of all patients.

Keywords: Adult; Aged; Brain Neoplasms /diagnostic imaging/; Female; Humans; Male; Middle Aged; Radionuclide Imaging; Radiosurgery; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome