Vnitr Lek 2001, 47(9):621-626

[In vitro testing for drug resistance and drug sensitivity in clinical oncology].

I Kiss, J Zaloudík, R Vyzula, J Tomásek, J Maláska, O Coufal, I Kocáková
Univerzitní onkologické centrum, oddĕlení klinické onkologie FN Brno, pracovistĕ Bohunice.

In vitro methods for testing chemosensitivity and chemoresistance can contribute considerably to more individual chemotherapy of a given patient. Different tests which reflect with a different reliability and specificity the probable ineffectiveness of chemotherapy can be divided into several categories: 1. Indirect tests associated with general biological activity of the tumour. 2. Tests based on the specific relationship to a certain cytostatic. 3. Examination of hormonal receptors. 4. Direct tests based on testing of the sensitivity or resistance of a tumour to different cytostatics in primocultures or stabilized cultures. The submitted review presents information on different methods.

Keywords: Animals; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor /methods/; Humans; Tumor Cells, Cultured /drug effects/

Published: September 1, 2001  Show citation

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Kiss I, Zaloudík J, Vyzula R, Tomásek J, Maláska J, Coufal O, Kocáková I. [In vitro testing for drug resistance and drug sensitivity in clinical oncology]. Vnitr Lek. 2001;47(9):621-626.
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