Locoregional chemotherapy is one of the possible ways of treatment of inoperable metastatic affection of the liver by colorectal carcinoma. The advantage of regional administration of the cytostatic is the possibility to achieve a higher local concentration of the cytostatic associated with a higher percentage of therapeutic responses. In our department we preferred combined locoregional intraarterial chemotherapy (5-fluorouracil/Mitmycin C/Doxorubicin) combined with systemic intravenous chemotherapy (5-fluorouracil/leukovirin). Locoregional cghemotherapy was administered in the majority as chemotherapy of series 2 or 3 with a very good tolerance. In 2/19 patients we observed marked diminution of liver metastases and subsequent operability and with a duration of complete response for 13 and 18 months. In 7/19 patients a partial therapeutic response was achieved. The total therapeutic response (complete and partial) was 47%. Locoregional chemotherapy attains a higher therapeutic response as compared with systemic chemotherapy and is associated with an acceptable toxicity.

Keywords: Antineoplastic Combined Chemotherapy Protocols /administration & dosage/; Carcinoma /drug therapy/; Colorectal Neoplasms /pathology/; Doxorubicin /administration & dosage/; Female; Fluorouracil /administration & dosage/; Humans; Infusions, Intra-Arterial; Leucovorin /administration & dosage/; Liver Neoplasms /drug therapy/; Male; Middle Aged; Mitomycin /administration & dosage/; Retrospective Studies