Vnitřní lékařství, 1989 (vol. 35), issue 12
[The present state and perspectives of postgraduate education of physicians in internal medicine].
R Rath
Vnitr Lek 1989, 35(12):1145-1150
Postgraduate training in internal medicine, although conceived as a programme for the entire productive life, is most intensive during the preparation for specialization examinations in the discipline. These examinations have two grades. Grade I can be obtained after attendance of a prescribed training and grade II after another four years. The author gives an account of the existing opportunities for training for specialization I in internal medicine (supplementary courses are organized in some regions) and grade II for which the Institute for Postgraduate Medical Training organizes three-month courses in Prague. In these courses not only the acquisition...
[Blood group Du].
M Hrubisko, D Cupaníková, L Ceizelová, D Pavlíková
Vnitr Lek 1989, 35(12):1151-1157
When examining blood group D, sensitive methods must be used which will detect false Du as D positive. When these methods are used the incidence of true Du is low, 1-2 pro mille. Moreover Du positive erythrocytes are practically not immunogenic, they may only be able to stimulate a secondary immune response, as easily revealed during antibody screening and during cross-matching. Their immunoreactivity is also low, a passively administered anti-D antibody does not eliminate them from the circulation. The clinical impact of true Du is therefore doubtful. There are also doubts as to the practical value of examination of Du. The authors submit their views...
[Monoclonal antibodies against erythrocyte antigens. Present status].
A Májský
Vnitr Lek 1989, 35(12):1158-1163
The author summarizes the contemporary state of the problem of monoclonal antibodies against red cell antigens. He discusses the possible use in immunohaematology. Conditions are outlined which must be met for ther use as diagnostic sera.
[Interferon alpha in the treatment of malignant hematologic diseases].
M Steruská
Vnitr Lek 1989, 35(12):1164-1170
The majority of malignant haematological diseases is incurable by contemporary procedures and therefore new approaches are sought, based on recent findings on haematopoiesis and its regulation. One of the new approaches is the use of so-called biological response modifiers between the later interferons. Recently relatively abundant experience was assembled with therapy using alpha interferon. The author presents an account of hitherto achieved therapeutic results obtained with alpha interferon in neoplasias of myelopoiesis and lymphopoiesis.
[Clinico-biochemical characteristics of patients with congenital glucose-6-phosphate dehydrogenase deficiency in erythrocytes].
A Sakalová, G Jacobasch, V Brabec
Vnitr Lek 1989, 35(12):1171-1176
The authors submit a clinical and biochemical investigation of five families with a congenital glucose-6-phosphate dehydrogenase red cell deficiency. Congenital nonspherocytic haemolytic anaemia was detected only in one hemizygous carrier, in four there was latent haemolysis with intermittent haemolytic crises and hyperbilirubinaemia. In 14 relatives carriership was revealed without clinical manifestations. The authors give a biochemical characteristic of kinetic properties of enzymatic variants according to WHO instructions (enzyme activity, thermal stability, pH stability and other kinetic constant) and emphasize the need to improve the diagnosis.
[Treatment of medium and highly malignant non-Hodgkin's lymphoma with combined chemotherapy using methotrexate, adriamycin, cyclophosphamide, vincristine, prednisone and bleomycin (protocol MACOP-B)].
H Pittrová, V Koza, V Vozobulová, P Cetkovský, P Skopek, J Jungerová, V Cepelák
Vnitr Lek 1989, 35(12):1177-1182
Combined chemotherapy, protocol MACOP-B, was administered to 21 patients with non-Hodgkin lymphoma (NHL) with a medium or high grade of malignity, clinical stage II-IV. Complete remission was achieved in 17 patients (81%), in one instance partial remission was induced. One patient died from a cardiovascular and one from a thromboembolic complication during treatment. In one patient the results were not evaluated. Three patients developed severe granulocytopenia which called for reduction or delay of treatment and a septic condition developed. In addition to myelosuppression the main complications were stomatitis and mycosis. No death caused by infectious...
[Thyroid gland function after short-term administration of amiodarone and digoxin].
B Renker, E Augustín, J Vavrík, A Lehotská, M Hajduchová
Vnitr Lek 1989, 35(12):1183-1189
The authors administered to 13 patients with auricular fibrillation amiodarone (Cordarone), 1200 mg/day, by the oral route from the 4th to the 10th day of the trial, 600 mg per day from the 11th to the 13th day of the trial. Simultaneously the patients were given digoxin, 1 mg, by the i.v. route: on the first day 1 mg i.v., 2nd to 5th day 0.5 mg i.v., and on the 6th to 10th day of the trial 0.25 mg. They assessed the serum digoxin concentration on the 1st, 4th, 11th and 14th day, the serum concentration of triiodothyronine (T3), thyroxine (T4) and thyrotropic hormone (TSH) on the 1st and 14th day of the trial. The authors revealed that after ten days...
[Differential diagnosis of acute myocardial infarct in hypothyroidism].
J S»ásek, V Pidrman, Z Hrncír, M Tichý, J Horácek
Vnitr Lek 1989, 35(12):1190-1194
The authors demonstrate the case of a female patient with hypothyroid myopathy where they recorded repeatedly a rise of enzymes used for the diagnosis of acute myocardial infarction, whereby myocardial infarction was not revealed. The authors followed up the disease for two years. They evaluated the relationship between the state of substitution and the activity of the mentioned enzymes and myoglobin.
[The effect of molsidomine on bicycle ergometry in patients with stable angina pectoris].
P Rotrekl, Z Lupínek, J Meluzín, F Rysavý, Z Lupínková
Vnitr Lek 1989, 35(12):1195-1202
The authors investigated the effect of a single dose of 4 mg molsidomine on the course of bicycle ergometry. This effect was compared with that of 120 mg isosorbide dinitrate retard and with placebo. Isosorbide dinitrate in this large dose significantly protracted the period before angina pectoris developed after exercise, it significantly reduced the duration of stenocardias, significantly increased the total work output, significantly prolonged the period before a reduction of the ST segment occurred on the ECG and significantly reduced the values of reduction of the ST segments. Moisidomine in medium doses significantly protracted the period before...
[Measurement of keratan sulfate levels in synovial fluid in joint diseases].
K Pavelka, M J Seibel, W Müller
Vnitr Lek 1989, 35(12):1203-1210
The authors describe their own modification of the ELISA method for the assessment of the epitope of keratate sulphate (KS) in synovial fluid. Considerably elevated values of KS were found in patients with gouty arthritis and reactive arthritis, as compared with patients with rheumatoid arthritis. The KS levels in the exudate of patients with osteoarthritis were significantly higher than in patients with rheumatoid arthritis. In patients with rheumatoid arthritis a negative relationship was found between the KS level in the exudate and the activity of the disease. A relationship was found between KS in the exudate and the interleukin-1 level in the...
[Anabolic effects of vitamin D in patients with osteomalacia].
J Kocián
Vnitr Lek 1989, 35(12):1211-1219
The author examined a group of 143 patients with osteomalacia of different origin before treatment and after adequate treatment with vitamin D, using laboratory tests, assessment of body weight and muscular strength (grip of the dominant hand). After treatment there was a significant rise of calcaemia, phosphataemia and calciuria and a drop of alkaline phosphatase activity. The body weight increased within the first month of treatment on average by 1.27 kg, during the second month by another 1.15 kg. The patients gained a total of 2.42 kg. The muscular strength increased during the first month on average by 3.23 kg and during the second month by another...