Geriatrie jako interdisciplinární vědní obor na prahu 21. století - editorial

J. Přehnal

Vnitr Lek 2005, 51(2):143  

Adiponektin - nový adipocytární hormon ve vztahu k obezitě a inzulinové rezistenci - editorial

V. Hainer

Vnitr Lek 2005, 51(2):144  

Heparinem indukovaná trombocytopenie (HIT) - editorial

J. Malý

Vnitr Lek 2005, 51(2):145-147  

Heparinem indukovaná trombocytopenie - editorial

J. Novotný

Vnitr Lek 2005, 51(2):148-152  

Smíšená kryoglobulinemie jako extrahepatální manifestace infekce virem hepatitidy C - editorial

P. Urbánek

Vnitr Lek 2005, 51(2):153-156  

Vyšetření aktivity destičkových funkcí se vztahem k rezistenci na kyselinu acetylsalicylovou - editorial

J. Malý

Vnitr Lek 2005, 51(2):157-162  

Pedal bypass in the treatment of diabetic foot ischemia - midterm results

P. Tošenovský, B. Zálešák, L. Janoušek, B. Kožnar, J. Peregrin

Vnitr Lek 2005, 51(2):163-166  

Background:Unacceptably high percentage of diabetics undergo major amputation of their lower limbs annually. An occlusive aterosclerosis of crural arteries is major cause of amputations of those patients. The end stage of such process is development of ulcerations and gangrene of the foot. A progress in revascularisation techniques led to a more aggressive approach to solve this issue within last few years and specially methods of interventional radiology reached good results in the inrapopliteal region. However the scope of percutaneous techniques is limited and fail in defined number of patients. Pedal bypass is a good alternative for...

Pulse pressure in the young population detected by ABPM and it's relation to metabolic and anthropometric parameters

J. Pařenica, L. Pinková, O. Ludka, P. Fráňa, H. Němcová, J. Špinar

Vnitr Lek 2005, 51(2):167-174  

Elevated value of pulse pressure (PP) is a predictor of increased cardiovascular mortality and morbidity. Ambulatory twenty four hour blood pressure monitoring (ABPM) shows a close correlation with end organ damage comparing with office blood pressure. The aim of this trial was to determine mean values of PP detected by ABPM in population aged 18-30 years, to determine variability of PP during day, to determine correlation between PP and systolic and diastolic blood pressure, heart rate and some risk factors of atherosclerosis. We have examined 252 probands (average age 23.6 ± 3.8, 55.2% were women). In this study the men population had significantly...

Apoptosis assessment in acute myeloid leukemia and B-cell chronic lymphocytic leukemia cells after in vitro cytostatics treatment and its relationship to multidrug resistance

K. Jankovičová, J. Krejsek, O. Kopecký, J. Voglová, Z. Škrabková, J. Novosad

Vnitr Lek 2005, 51(2):175-182  

Apoptosis failure during chemotherapy of leukemia is one of the multidrug resistance mechanisms. The aim of this study was to introduce in vitro model for malignant cell clone sensitivity testing. In vitro cytostatic treatment of acute myeloid leukemia (AML) and B-cell chronic lymphocytic leukemia (B-CLL) cells and its relationship to P-gp, MRP, LRP, Bcl-2, and Bax proteins expression was also investigated. AML cells were treated with doxorubicin and B-CLL cells were treated with chlorambucil. Flow cytometry was used for all experiments evaluation. To detect the amount of apoptotic cells in the sample three methods were used: annexin test, TUNEL (Tdt-mediated...

Personal experience with the origin and duration of spontaneous remission in adult type 1 diabetics

M. Voborská, K. Vondra, V. Zamrazil

Vnitr Lek 2005, 51(2):183-189  

Objective of the Research:Purpose of the present study was to obtain personal experience related to the occurrence and duration of spontaneous remission (R) in recent adult type 1 diabetics. Patients and Methods:Analysis of retrospective data of 40 long-term monitored adult type 1 diabetics (diagnosed at the age of 25.3 ± 5.7 years; 21 men, 19 women) revealed many pieces of knowledge, some of them being absolutely novel and unpublished in the scientific literature yet. Results:Totally 60% of patients (i.e. 24 patients) developed remission, 17% exhibited complete remission and remaining 43% partial remission....

The influence of combined aerobic and resistance training on left ventricle function in patients after acute myocardial infarction

L. Elbl, V. Chaloupka, I. Tomášková, F. Jedlička, S. Nehyba, P. Kala, J. Schildberger, M. Poloczek, O. Boček

Vnitr Lek 2005, 51(2):190-197  

Objective of the Research:Presented research was focused on the evaluation of the influence of combined aerobic training with resistance exercise performed within early controlled ambulatory rehabilitation on the left ventricle function in patients after the first acute myocardial infarction. Patients and Methods:109 patients (18 women, 91 men) at the age of 58 ± 9 years were enrolled into the study. 34 patients (38 ± 6 %) exhibited decreased ejection fraction (EF) < 50 %. The time interval from the occurrence of myocardial infarction to the beginning of the rehabilitation was 31 ± 7 days, in patients...

Geriatrics as an inter-disciplinary science on the threshold of the 21^st century

P. Weber

Vnitr Lek 2005, 51(2):198-205  

Author in his review refers to geriatrics as a peculiar scientific branch with a close relationship to internal medicine. Internal medicine is in fact a basic source for everyday clinical practice of geriatrician. However, there are some additional specific methods and approaches used while treating seniors. In addition to the basic characteristics of geriatrician's work the review highlights the importance of function examination in geriatrics, which, in addition to the physical evaluation, should stress the evaluation of self-sufficiency as well as mental and social status. Furthermore, the author analyses population age structure and associated...

Stem cells: new promise in medicine

M. Klabusay, P. Dvořák, J. Mayer

Vnitr Lek 2005, 51(2):206-215  

The stem cells - both embryonic and adult - attract the attention of scientific and medical community nowadays. They could become a key to the treatment of serious diseases, because of their ability of the long-term self-renewal and differentiation. Many scientists around the world pay attention to stem cells research. This article gives a brief overview of the state-of-the-art of our knowledge about the human stem cells. In the introduction, the definition of stem cells and their nomenclature are described. In the chapter about embryonic stem cells, historical background, proof of pluripotency, and potential therapeutical applications are summarized....

Tumor lysis syndrome

A. Kafková, E. Tóthová

Vnitr Lek 2005, 51(2):216-220  

Tumor lysis syndrome with hypeuricemia, also known as TLS, is a potentially serious complication of cancer chemotherapy and it can result in life-threatening complications such as renal failure and cardiac arrhythmias. The aim of this paper is to provide a general overview of the pathophysiology and corresponding signs and symptoms of TLS and review clinical and laboratory monitoring parameters. An understanding of the pathophysiology of TLS and meticulous assessment of signs and symptoms and monitoring of the laboratory data, as well as early recognition of problems are essential for optimal patient outcomes. Both allopurinol and rasburicase offer...

Adiponectin - the new adipocyte-derived hormone with relation to obesity and insulin resistance

J. Housová, D. Housa, M. Haluzík

Vnitr Lek 2005, 51(2):221-225  

It is generally accepted that adipose tissue is an endocrine organ producing number of hormones. These hormones play an important role in the food intake regulation and significantly affect the development of atherosclerosis and insulin resistance respectively. Adiponectin - a recently discovered adipocyte-derived hormone - is one of the most extensively studied adipocytokines. There is a growing number of both experimental and clinical evidence suggesting that adiponectin is an important ethiopathogenic factor in the development of insulin resistance, diabetes and atherosclerosis. The aim of this article is to review the current state of knowledge...

Congenital adrenal hyperplasia, defect of 17α-hydroxylase as a rare cause of hypertension and hypocalaemia

V. Olšovská, J. Šulcová, A. Hondlová, H. Šiprová

Vnitr Lek 2005, 51(2):226-230  

Authors describe infrequently occurring case of congenital adrenal hyperplasia, partial defect of 17α-hydroxylase in female patient with hypertension, hypocalaemia, menstrual cycle disorders and sterility. Diagnosis was established on the basis of native examination of steroid spectrum together with both stimulation and suppression tests and CT examination. After the treatment with dexamethason was established, the blood pressure and electrolyte levels reached the correction. This report supports the importance of the whole steroid spectrum examination in the patients with this symptomatology in order to eliminate rare causes of endocrine hypertension.

Heparin-induced thrombocytopenia in a patient with left main coronary artery stenosis

J. Hirmerová

Vnitr Lek 2005, 51(2):231-237  

The article describes a case of a 75 year old female patient with hypertension and chronic atrial fibrillation, admitted for shortness of breath and chest pain. Coronarography revealed a significant stenosis of the left main coronary artery. The patient was indicated to coronary artery bypass grafting. During the stay, low molecular weight heparin had been applied. In the third week the platelet count fell down markedly and several days later, heparin necrosis developed in a place of subcutaneous heparin application in abdominal wall. Laboratory assays confirmed the presence of the antibodies against the heparin/platelet factor 4 complex. Thus the...

Treatment of chronic infection with hepatitis C virus with pegylated interferon and ribavirin in patient with mixed cryoglobulinaemia

P. Husa, Z. Adam, L. Husová, J. Feit, M. Penka, Z. Čermáková

Vnitr Lek 2005, 51(2):238-243  

Mixed cryoglobulinaemia is the most common extrahepatic manifestation of hepatitis C virus (HCV) infection. Anti-HCV antibodies and ribonucleic acid of the virus, HCV RNA, can be detected in cryoprecipitates, together with rheumatoid factor. Cryoglobulins consist of complex of immunoglobulins that in vitro precipitate upon the cooling bellow the human body temperature. Vasculitis is caused by the deposition of such immunocomplexes in the small blood vessels. 36-45% of patients chronically infected with HCV have cryoglobulins in serum; however, less than 10% of them develop clinically manifested vasculitis. In the referred patient sporadic eruption...

Radovan Slezák et al. Malé ilustrované repetitorium

L. Chrobák

Vnitr Lek 2005, 51(2):253-254  

Pavel Ševčík, Jana Skřičková, Vladimír Šrámek et al. Záněty plic v intenzivní medicíně

V. Kolek

Vnitr Lek 2005, 51(2):254  

Stanislav Havelka, Jozef Hoza et al. Revmatologie období růstu. Diagnostika, terapie, rehabilitace

P. Němec

Vnitr Lek 2005, 51(2):255  

Pavel Maruna. Proteiny akutní fáze. Fyziologie, diagnostika, klinika

J. Litzman

Vnitr Lek 2005, 51(2):255-256  

Jiří Widimský jr et al. Arteriální hypertenze - současné klinické trendy

J. Špác

Vnitr Lek 2005, 51(2):256  

Pavel Kohout et al. Výživa u pacientů s idiopatickými střevními záněty

B. Kianička

Vnitr Lek 2005, 51(2):257  

Jan Příborský: Peniciliny

R. Tejkalová

Vnitr Lek 2005, 51(2):257  

Redakční pošta

P. Svačina

Vnitr Lek 2005, 51(2):244  

Redakční pošta

M. Pecka

Vnitr Lek 2005, 51(2):244-245  

Redakční pošta

B. Lačňák, D. Stejskal

Vnitr Lek 2005, 51(2):245-248  

Studium na lékařské fakultě - potřeba tradice i změn

J. Žaloudík

Vnitr Lek 2005, 51(2):249-252  

XI. sjezd České internistické společnosti Brno 20.-23. října 2004

J. Widimský jr.

Vnitr Lek 2005, 51(2):259