Indikátory zánětu u pacientů s koronární aterosklerózou - editorial

F. Málek

Vnitr Lek 2013, 59(12):1037-1038  

Komentář ke studii EDGE - editorial

M. Honka

Vnitr Lek 2013, 59(12):1039-1040  

Pozice tiotropia v nových léčebných doporučeních pro chronickou obstrukční plicní nemoc - editorial

V. Kašák

Vnitr Lek 2013, 59(12):1041-1042  

Prospective, multicentric, non-interventional study to assess the existing treatment of type 2 diabetes mellitus patients inadequately controlled with metformin monotherapy - KOMETA CZ

Š. Svačina, V. Veselá

Vnitr Lek 2013, 59(12):1043-1048  

After several years of diabetes, the first line anti-diabetic therapy of metformin usually starts failing. The KOMETA study was a prospective, multicentric, non-interventional epidemiological study in patients with type 2 diabetes mellitus inadequately controlled with metformin therapy. The study was conducted between 2010 and 2011. The study demonstrated a significant improvement in diabetes control, reduction of waist circumference, reduction in blood pressure and adjustment of dyslipidemia compared to baseline. Based on this study, our doctors select anti-diabetic drugs responsibly and they often use medicines without the hypoglycaemia risk. Nevertheless,...

Efficacy and safety of vildagliptin as a second-line therapy vs other oral antidiabetic agents in patients with type 2 diabetes: Czech results within the worldwide prospective cohort EDGE study

M. Haluzík, V. Veselá, J. Gerle, M. Brada, L. Dohnalová, T. Edelsberger, J. Houdová

Vnitr Lek 2013, 59(12):1049-1056  

Introduction:Metformin monotherapy is recommended as initial treatment of type 2 diabetes. The selection of optimal second-line therapy that is often necessary due to the progressive nature of the disease is still a subject of ongoing discussions. Aim of the study:The aim of the international EDGE ( Effectiveness of Diabetes control with vilda Gliptin and vildagliptin/m Etformin) study was to prospectively compare the efficacy and safety of vildagliptin vs other oral antidiabetic agents in patients with type 2 diabetes not adequately controlled on monotherapy in a real-life clinical setting. In...

Present and future of pharmaco-arteriothromboprophylaxis in clinical practice. Guidelines of Angiology Section of Slovak Medical Chamber

P. Gavorník, A. Dukát, Ľ. Gašpar

Vnitr Lek 2013, 59(12):1081-1087  

Antiplatelet therapy by acetylsalicylic acid (aspirin) provided pivotal advances in the prevention and treatment of organovascular (cardiovascular, cerebrovascular, extremitovascular, renovascular, genitovascular, mesenteriovascular, bronchopulmovascular, oculovascular, otovascular and other) arterial ischemic diseases. Currently available antiplatelet drugs have some limitations which might be overcomed by improved dosing regimens, use of combination of agents affecting different platelet functions and, in particular, by the new antiplatelet drugs (new arterial antithrombotics) with distinct pharmacodynamic properties offering new advantages, including...

Doporučené postupy v léčbě starších pacientů s diabetes mellitus v ČR

Š. Svačina, B. Jurašková, I. Karen, A. Šmahelová, J. Olšovský, R. Červený, I. Holmerová, T. Pelikánová

Vnitr Lek 2013, 59(12):1088-1095  

Doporučení KDIGO pro léčbu zvýšeného krevního tlaku u chronického onemocnění ledvin

V. Monhart

Vnitr Lek 2013, 59(12):1096-1106  

Indicators of inflammation in patients with coronary atherosclerosis - role of usCRP in diagnosis and disease progression prediction

M. Samoš, R. Pullmann, S. Funiak, M. Stančík, M. Mokáň

Vnitr Lek 2013, 59(12):1057-1064  

Atherosclerosis is being nowadays defined as chronic subclinical inflammatory disease. Recently published clinical and laboratory studies have shown that subclinical inflammation represents main role in initiation of creation, in progress and destabilization of atherosclerotic plaque. Screening including traditional cardiovascular risk factors fails in identification in more than 50% of individuals with later development of acute coronary syndrome. According to above mentioned reason indicators are being searched for, which would be usable to monitor the activity of atherosclerotic process. According to role of subclinical inflammatory process in pathogenesis...

Contemporary view on liver impairment in heart failure

K. Vyskočilová, L. Špinarová

Vnitr Lek 2013, 59(12):1065-1072  

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided forward failure and on the venous congestion in the right-sided backward failure. Current studies dealing with the cardiac hepatopathy focus not only on the liver enzyme changes, but also analyse its clinical and prognostic relevance. The aim of the article is to provide the comprehensive and contemporary view on liver dysfunction in heart failure patients.

The position of tiotropium in new treatment guidelines for chronic obstructive pulmonary disease

V. Koblížek

Vnitr Lek 2013, 59(12):1073-1080  

Chronic obstructive pulmonary disease is a significant syndrome of internal medicine with serious health, social and economic impacts. Globally, tiotropium is the longest used and through the randomised studies the most examined representative of inhalation long-acting antimuscarinics. In routine practice, this treatment group is identified with a globally known abbreviation LAMA (or U-LAMA, U means ultralong-acting with dosing every 24 hours). Pharmacological agents of the LAMA (U-LAMA) group are included in a significant number of all important treatment guidelines. The Czech guidelines place these medicines into the first line of general medication...

Inflammatory borrelia - associated dilated cardiomyopathy

K. Plocarová

Vnitr Lek 2013, 59(12):1107-1110  

A case of a 44-year-old female patient is described, examined for several weeks with shortness of breath and the symptoms of heart decompensation after repeated untreated respiratory infections. Echocardiographically determined diffuse hypokinesis of dilated left ventricle with ejection fraction of 20%. Coronarographic examination without any significant finding at the coronary bed. MRI of the myocardium supported the suspicion of myocarditis, followed by the endomyocardial biopsy with electron microscopic evidence of borrelia fragments. After the causal and symptomatic treatment, the patient experienced significant clinical improvement and full normalisation...

Serious risk related to oral use of sodium phosphate solution

I. Hoffmanová, M. Anděl

Vnitr Lek 2013, 59(12):1111-1116  

Sodium phosphate solutions are commonly used to cleanse the bowel in preparation for colonoscopy, for barium enema or surgical procedures and eventually for treatment of severe constipation. Though relatively safe, these drugs must be used with caution in patients with kidney disease, small intestinal disorders, or poor gut motility and are prohibited in renal insufficiency and bowel obstruction. Especially elderly patients are at increased risk for phosphate intoxication due to decreased glomerular filtration rate, concomitant medication use, and systemic and gastrointestinal diseases. Sodium phosphate solution could induce by at-risk patient's serious...

Histiocytic sarcoma

E. Létalová, M. Moulis, M. Klincová, R. Koukalová, Z. Řehák, F. Folber, Z. Adam, J. Mayer

Vnitr Lek 2013, 59(12):1117-1122  

Histiocytic sarcoma is a neoplasm arising from the histiocytes. Histiocytic neoplasms are among the rarest malignancies of lymphatic tissues. Occurs in less than 1% of all malignancies affecting lymph nodes and soft tissues [1,2]. The exact incidence of histiocytic sarcoma has not been described so far. In this article, we report three patients with HS, who were treated at the departement of Internal medicine, haematology and oncology, Faculty Hospital Brno. Despite the fact that all these patients had the same disease, the treatment effects differ depending on the stage of the disease at the time of diagnosis.

Effects of the angiotensin receptor blocker Valsartan (Valsacor®) on arterial pressure, indices of myocardial diastolic function and global longitudinal strain in patients with uncontrolled arterial hypertension

K. Vitlyanova, S. Naidenov, N. Runev, E. Manov, R. Shabani, Y. Rangelov, K. Koshtikova, T. Donova

Vnitr Lek 2013, 59(12):1124-1128  

The objective of this study was to evaluate the effects of Valsartan (Valsacor®) on arterial pressure (AP) and indices of myocardial diastolic and global function in patients with uncontrolled arterial hypertension (AH). Material and methods:60 patients (39 men and 21 women, mean age 63.9 ± 10.8 years, P > 140/90 mmHg with a background of combined antihypertensive therapy) were involved in the study. Valsartan (Valsacor®) was added to the standard therapy. The follow-up continued for three months, with clinical visits at initiation and completion of the study. The echocardiographic (EchoCG) evaluation included measurements...

Mechanizmus pleiotropního účinku sulodexidu

Viera Kristová

Vnitr Lek 2013, 59(12):1130-1131  

Rifaximin v léčbě jaterní encefalopatie

Martin Vaněk

Vnitr Lek 2013, 59(12):1133-1134  

Recenze (Z odborné literatury)

Prim. MUDr Zdeněk Monhart, Ph.D.

Vnitr Lek 2013, 59(12)

Recenze (Z odborné literatury)

MUDr. Petr Žák

Vnitr Lek 2013, 59(12)

Recenze (Z odborné literatury)

Doc. MUDr. Jiří Motáň, CSc.

Vnitr Lek 2013, 59(12)