Využití natriuretických peptidů v diagnostice hypertrofie levé komory u obézních hypertoniků s metabolickým syndromem - editorial

V. Adámková

Vnitr Lek 2013, 59(9):759  

Jak zlepšit adherenci k lékovému režimu u klinicky komplexních polymorbidních seniorů? Editorial

E. Topinková

Vnitr Lek 2013, 59(9):760-763  

Does physical activity produce clinically significant changes during discontinuation of insulin pump in type 1 diabetic patients?

Z. Jankovec, D. Čechurová, V. Česák, M. Krčma, M. Žourek, Z. Rušavý

Vnitr Lek 2013, 59(9):764-768  

Introduction:Discontinuation of insulin pump treatment (CSII) before, during and after physical activity is a common practice among a number of patients. The aim of the study was to evaluate the course of insulinemia during a 3-hour insulin pump suspension and after consecutive insulin bolus administration, and additionally, to assess the effect of physical activity (mid-intensity aerobic exercise). Patient and methods:We enrolled 12 patients with diabetes mellitus type 1 in the study (men, mean age 33.4 ± 8.66 years, diabetes duration 16.3 ± 8.76 years, CSII treatment duration 6.9 ± 4.60 years, BMI 25.7...

Use of natriuretic peptides in diagnosis of left ventricular hypertrophy in obese hypertensive patients with metabolic syndrome

J. Špác, M. Beránek, H. Němcová, B. Kianička, M. Souček

Vnitr Lek 2013, 59(9):769-775  

Introduction:Presence of left ventricular (LV) hypertrophy significantly increases cardiovascular risk in patients suffering from hypertension. Diagnostics of LV hypertrophy in hypertensive patients is not easy and there is still no method of enabling a simple and sufficiently sensitive diagnosis across a large patient population. The golden standard in LV hypertrophy diagnostics is echocardiography, and there are adverse opinions regarding the use of natriuretic peptides BNP and NT-proBNP (NP) to diagnose LV hypertrophy. Patients and methods:We examined through echocardiography 173 hypertensive patients with signs of metabolic...

The importance of cardiac biomarker assay for the stratification and monitoring of AL amyloidosis patients - single center experience

T. Pika, P. Lochman, J. Vymětal, R. Metelka, P. Flodr, J. Minařík, P. Látalová, J. Zapletalová, J. Bačovský, V. Ščudla

Vnitr Lek 2013, 59(9):776-781  

Introduction:Cardiac involvement is a dominant prognostic factor in AL amyloidosis patients. A detailed assessment of the presence and degree of cardiac involvement utilizes an array of non-invasive investigation methods, particularly echocardiography and MRI; laboratory parameters include troponins and natriuretic peptides. Cardiac involvement detection aside, cardiac biomarkers are used as a relatively strong stratification and prognostic factor. Objective:The presentation of cardiac biomarkers assay applications in AL amyloidosis patients at an individual treatment center. Patients and methods:The monitored...

Assessment of selected markers of apoptosis and angiogenesis in chronic lymphocytic leukemia

M. Motyčková, L. Smolej, C. Andrýs, V. Řezáčová, V. Řeháček, M. Šimkovič, D. Belada, P. Žák

Vnitr Lek 2013, 59(9):782-793  

Introduction:Search for new prognostic markers in order to improve prognostic accuracy and predict clinical outcome at the time of diagnosis has recently become one of the major trends in chronic lymphocytic leukemia (CLL). Patients and methods, aim of study:The aim of our study was assessment of selected markers of apoptosis and angiogenesis and their potential as new prognostic factors. We evaluated serum levels of tumor necrosis factor α (TNF-α) and transforming growth factor β-1 (TGF-β1) using comercially available enzyme-linked immunosorbent assay; furthemore, we quantified expression of type II...

Compliance of senior/elderly patients with cognitive impairment

B. Vepřeková, A. Pokorná

Vnitr Lek 2013, 59(9):794-799  

The contribution presents the results of investigation conducted at a department of the Long-term Care and Rehabilitation Centre of The Merciful Brothers' Hospital in Brno. Altogether, 100 seniors were examined, 20 men and 80 women, with an average age of 81.6 ± 6.88 years and an age range of 70 to 98 years. The well-known and repeatedly demonstrated errors in the therapeutic regime of the patients, especially older seniors, compel us to focus our attention on consistent prevention of these situations. The present work summarises the knowledge about the diminished compliance of geriatric patients. It compares the mutual relationship of cognitive...

RESOLUTE Study in the Czech Republic: insulin glargine improves the compensation of type 2 diabetes in patients with unsatisfactory results of therapy with a combination of insulin detemir and oral antidiabetics. Results of the non-intervention RESOLUTE Project in the Czech Republic

M. Kvapil

Vnitr Lek 2013, 59(9):800-806  

Introduction:The RESOLUTE was a multinational, non interventional, 6 month prospective observational project evaluating in clinical practice, whether patients with type 2 diabetes mellitus (T2DM) inadequately controlled with detemir in combination with oral anti-diabetic drugs (OADs) may benefit from switching to glargine. In Czech Republic 200 patients, for whom the participating physician according to their own consideration, had decided to prescribe insulin glargine in replacement of insulin detemir, were included in this project. Objectives:The primary endpoint was to assess the change in HbA_1c over the 6-month...

Recommendation of the Czech society of Endocrinology for the treatment of Cushing's syndrome in adults

M. Kršek, J. Čáp, V. Hána, J. Marek

Vnitr Lek 2013, 59(9):819-827  

Cushing's syndrome is a rare disorder with variable aetiology which is connected with significantly increased morbidity and mortality. Therefore, early determination of correct aetiology and early treatment are essential for a decrease of morbidity and mortality of patients. Present article introduces review and current recommendation of Czech Society of Endocrinology for the treatment of Cushing's syndrome.

Food intake regulation - 1^st part

L. Brunerová, M. Anděl

Vnitr Lek 2013, 59(9):808-817  

The review article summarizes a very complex process of appetite regulation: the part focused on homeostatic regulation of food intake. The aim of homeostatic regulation is to achieve energy balance, stabile weight and optimal nutrient intake, in contrast to hedonic regulation of food intake, in which emotional and motivational factors are involved. Homeostatic regulation could be divided into short-term and long-term regulation and comprises mainly gastrointestinal peptides, fat tissue hormones and central mechanisms localized in hypothalamus. It is a resultant of the action of orexigenic factors (increasing appetite and food intake) and anorexigenic...

Cold agglutinin disease - no response to glucocorticoids and rituximab, what treatment is best for the 3^rd line of therapy? Case report and review of the literature

Z. Adam, A. Pejchalová, G. Chlupová, L. Říhová, L. Pour, M. Krejčí, L. Červinek, Z. Král, J. Mayer

Vnitr Lek 2013, 59(9):828-840  

Acquired autoimmune haemolytic anaemia is divided according to the characteristics of immunoglobulin causing haemolysis. The most frequent are haemolytic anaemia with thermal antibodies. They bind to erythrocytes and initiate their destruction in the reticuloendothelial system cells, leading to extravascular haemolysis. Cold agglutinin disease differs significantly from haemolytic anaemia with thermal antibodies. Agglutination is caused by monoclonal antibodies, in most cases class IgM and very rarely class IgG. Under cold conditions they bind to erythrocytes and cause their agglutination and subsequent disorder of blood circulation in body parts with...

Regional migrating osteoporosis - a case report

I. Žofková, J. Hrbáč, J. Dostál, J. Šprindrich

Vnitr Lek 2013, 59(9):841-845  

Regional migrating osteoporosis (RMO) was observed in young man with episodes of bone pain in bearing joints, which migrated from hip to leg and subsequently to knee on the unilateral side. Dynamic scintigraphy (SPECT) carried out during relapse of pain demonstrated increased accumulation of radioizotope in Lisfrank joint, distal epiphysis of femur and proximal epiphysis of tibia on the unilateral side due to hyperperfusion and high metabolic turnover in these regions of the skeleton. Diagnosis of RMO was confirmed by magnetic resonance (MRI), which showed bone marrow edema of corresponding regions. Although RMO is relatively benign disease with spontaneous...

Nová data a indikace pro sulodexid

Martin Vaněk

Vnitr Lek 2013, 59(9):847-848  

ERS 2013. Duální bronchodilatace aneb Ve dvou (se) to lépe táhne

Jana Tlapáková

Vnitr Lek 2013, 59(9):849-852  

Dabigatran - klinická zkušenost z více než dvou miliónů pacientoroků

Jan Kulhavý

Vnitr Lek 2013, 59(9):855-859